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Forgetting What You Have Checked: A Link Between Working Memory Impairment and Checking Behaviors in Obsessive-Compulsive Disorder

Published online by Cambridge University Press:  15 September 2011

N. Jaafari ,
M. Frasca ,
F. Rigalleau ,
F. Rachid ,
R. Gil ,
J.-P. Olié ,
D. Guehl ,
P. Burbaud ,
B. Aouizerate  and
J.-Y. Rotgé
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N. Jaafari*
Affiliation:
Unité de recherche clinique intersectorielle, centre hospitalier Henri-Laborit, 370, avenue Jacques-Coeur, 86021Poitiers, France CHU Poitiers, 2, rue de la Milétrie, BP 577, 86021Poitiers cedex, France Faculté de médecine et de pharmacie, université de Poitiers, 6, rue de la Milétrie, B9 199, 86034Poitiers cedex, France CIC-P Inserm U 802, 86000Poitiers, France
M. Frasca
Affiliation:
CNRS UMR 6234, centre de recherches sur la cognition et l'apprentissage, université de Poitiers, université François-Rabelais de Tours, maison des sciences de l'homme et de la société, Poitiers, France
F. Rigalleau
Affiliation:
CNRS UMR 6234, centre de recherches sur la cognition et l'apprentissage, université de Poitiers, université François-Rabelais de Tours, maison des sciences de l'homme et de la société, Poitiers, France
F. Rachid
Affiliation:
Unité de recherche clinique intersectorielle, centre hospitalier Henri-Laborit, 370, avenue Jacques-Coeur, 86021Poitiers, France Private practice, 7, place de la Fusterie, 1204Geneva, Switzerland
R. Gil
Affiliation:
Centre mémoire de ressources et de recherche, université de médecine et de pharmacie de Poitiers, CHU de Poitiers, 86000Poitiers, France
J.-P. Olié
Affiliation:
Laboratoire de physiopathologie des maladies psychiatriques, université Paris Descartes, Inserm U 894, service hospitalo-universitaire de santé mentale et thérapeutique, centre hospitalier Sainte-Anne, Paris, France
D. Guehl
Affiliation:
CNRS UMR 5293, institut des maladies neurodégénératives, université Bordeaux 2, Bordeaux, France
P. Burbaud
Affiliation:
CNRS UMR 5293, institut des maladies neurodégénératives, université Bordeaux 2, Bordeaux, France
B. Aouizerate
Affiliation:
CNRS UMR 5293, institut des maladies neurodégénératives, université Bordeaux 2, Bordeaux, France
J.-Y. Rotgé
Affiliation:
CNRS UMR 5293, institut des maladies neurodégénératives, université Bordeaux 2, Bordeaux, France
N. Vibert
Affiliation:
CNRS UMR 6234, centre de recherches sur la cognition et l'apprentissage, université de Poitiers, université François-Rabelais de Tours, maison des sciences de l'homme et de la société, Poitiers, France
*
⁎Corresponding author. Tel.: +33 05 49 44 58 02; fax: +33 05 49 44 58 00. E-mail address: n.jaafari@wanadoo.fr (N. Jaafari).
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Abstract

Background

Compulsive checking behaviors are common in obsessive-compulsive disorder (OCD). Several authors have suggested that these checking rituals could be related to memory deficits. Our aim was to test whether patients with OCD show working memory impairment in relation to their checking behavior.

Methods

We evaluated the verbal and visuospatial components of patients’ and controls’ working memory using the reading span and backward location span tests. Checking behaviors were measured by recording participants’ eye movements during an image comparison task using a non-invasive, infra-red TOBII 1750 eyetracker. Participants were seated, head-free, in a natural position in front of the eyetracker screen where the images were displayed.

Results

Patients with OCD made more gaze moves to compare images than controls. Both patients’ working memory spans were reduced, and the patients’ deficit in the comparison task was negatively related to their working memory spans.

Conclusions

This work demonstrates that checking behavior in OCD is linked to a general reduction of the patients’ verbal and visuospatial working memory span.

Keywords

Working memory spanEye movement recordingsImage comparison taskObsessive compulsive disorderChecking behavior

Information

Type
Original article
Information
European Psychiatry , Volume 28 , Issue 2 , February 2013 , pp. 87 - 93
Copyright
Copyright © Elsevier Masson SAS 2013

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References

Boldrini, M., De Pace, L., Placidi, G.P.A., Keilp, J., Ellis, S.P., Signori, S.et al.Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. Acta Psychiatr Scand 2005;111:150–158.CrossRefGoogle ScholarPubMed
Chamberlain, S.R., Blackwell, A.D., Finerberg, N.A., Robbins, T.W., Sahakian, J.The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev 2005;29:399–419.CrossRefGoogle ScholarPubMed
Chamberlain, S.R., Menzies, L., Hampshire, A., Suckling, J., Fineberg, N.A., del Campo, N.et al.Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 2008;321:421–422.CrossRefGoogle ScholarPubMed
Daneman, M., Carpenter, P.A.Individual differences in working memory and reading. J Verbal Learn Verbal Behav 1980;19:450–466.CrossRefGoogle Scholar
Desmette, D., Hupet, M., Schelstraete, M.A., Van der Linden, M.Adaptation en langue Française du “Reading span test” de Daneman et Carpenter (1980). Annee Psychol 1995;95:459–482.CrossRefGoogle Scholar
Eisen, J.L., Phillips, K.A., Baer, L., Beer, D.A., Atala, K.D., Rasmussen, S.A.The Brown assessment of beliefs scale: Reliability and validity. Am J Psychiatry 1998;155:102–108.CrossRefGoogle ScholarPubMed
Fontenelle, L.F., Mendlowicz, M.V., Mattos, P., Versiani, M.Neuropsychological findings in obsessive-compulsive disorder and its potential implications for treatment. Curr Psychiatry Rev 2006;2:11–26.CrossRefGoogle Scholar
Fournier-Vicente, S., Larigauderie, P., Gaonach, D.More dissociations and interactions within central executive functioning: a comprehensive latent-variable analysis. Acta Psychol 2008;129:32–48.CrossRefGoogle ScholarPubMed
Friedman, N.P., Miyake, A.Comparison of four scoring methods for the reading span test. Behav Res Meth 2005;37:581–590.CrossRefGoogle ScholarPubMed
Goodman, W.K., Price, L.H., Rasmussen, S.A., Mazure, C., Delgado, P., Heninger, G.R.et al.The Yale-Brown Obsessive Compulsive Scale: II. Validity. Arch Gen Psychiatry 1989;46:10012–10016.Google ScholarPubMed
Goodman, W.K., Price, L.H., Rasmussen, S.A., Mazure, C., Fleischmann, R.L., Hill, C.L.et al.The Yale-Brown Obsessive Compulsive scale: I. Development, use, and reliability. Arch Gen Psychiatry 1989;46:1006–1011.CrossRefGoogle ScholarPubMed
Grisham, J.R., Anderson, T.M., Poulton, R., Moffitt, T.E., Andrews, G.Childhood neuropsychological deficits associated with adult obsessive-compulsive disorder. Br J Psychiatry 2009;195:138–141.CrossRefGoogle ScholarPubMed
Jaafari, N., Aouizerate, B., Tignol, J., El-Hage, W., Wassouf, I., Guehl, D.et al.The relationship between insight and uncertainty in obsessive-compulsive disorder. Psychopathology 2011;44:272–276.CrossRefGoogle ScholarPubMed
Kuelz, A.K., Hohagen, F., Voderholzer, U.Neuropsychological performance in obsessive-compulsive disorder: a critical review. Biol Psychol 2004;65:185–236.CrossRefGoogle ScholarPubMed
Martinez-Gonzalez, A.E., Piqueras-Rodriguez, J.A.Neuropsychological update on obsessive-compulsive disorder. Rev Neurol 2008;46:618–625.Google ScholarPubMed
Mataix-Cols, D., Alonso, P., Pifarré, J., Menchon, J.M., Vallejo, J.Neuropsychological performance in medicated versus unmedicated patients with obsessive-compulsive disorder. Psychiatry Res 2002;109:255–264.CrossRefGoogle Scholar
Menzies, L., Achard, S., Chamberlain, S.R., Fineberg, N., Chen, C.H., Del Campo, N.et al.Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain 2007;130:3223–3226.CrossRefGoogle ScholarPubMed
Milner, B.Interhemispheric differences in the localization of psychological processes in man. Br Med Bull 1971;27:272–277.CrossRefGoogle ScholarPubMed
Mollard, E., Cottraux, J., Bouvard, M.Version française de l’échelle d’obsession-compulsion de Yale-Brown. Encephale 1989;15:335–341.Google Scholar
Rasmussen, S.A., Eisen, J.L.Epidemiology of obsessive compulsive disorder. J Clin Psychiatry 1990;51:10–13.Google ScholarPubMed
Rasmussen, S.A., Eisen, J.L.The epidemiology and differential diagnosis of obsessive compulsive disorder. J Clin Psychiatry 1992;53:4–10.Google ScholarPubMed
Rotgé, J.Y., Clair, A.H., Jaafari, N., Hantouche, E.G., Pelissolo, A., Goillandeau, M.et al.A challenging task for assessment of checking behaviors in obsessive-compulsive disorder. Acta Psychiatr Scand 2008;117:465–473.CrossRefGoogle ScholarPubMed
Schwartz, J.M.A role of volition and attention in the generation of new brain circuitry. Toward a neurobiology of mental force. J Consciousness Stud 1999;6:115–142.Google Scholar
Stein, D.J.Obsessive-compulsive disorder. Lancet 2002;360:397–405.CrossRefGoogle ScholarPubMed
Weissman, M.M., Bland, R.C., Canino, G.J., Greenwald, S., Hwu, H.G., Lee, C.K.et al.The cross-national epidemiology of obsessive-compulsive disorder. J Clin Psychiatry 55Suppl.1994:5–10.Google ScholarPubMed
Woods, C.M., Vevea, J.L., Cahmbless, D.L., Bayen, U.J.Are compulsive checkers impaired in memory? A meta-analytic review. Clin Psychol Sci Prac 2002;9:353–366.CrossRefGoogle Scholar
Zielinski, C.M., Taylor, M.A., Juzwin, K.R.Neuropsychological deficits in obsessive-compulsive disorder. Neuropsychiatr Neuropsychol Behav Neurol 1991;4:110–126.Google Scholar
Zitterl, W., Urban, C., Linzmayer, L., Aigner, M., Demal, U., Semler, B.et al.Memory deficits in patients with DSM IV obsessive-compulsive disorder. Psychopathol 2001;34:113–117.CrossRefGoogle ScholarPubMed
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