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Substance use and the course of early psychosis: a 2-year follow-up of first-admitted subjects

Published online by Cambridge University Press:  16 April 2020

F. Sorbara ,
F. Liraud ,
F. Assens ,
F. Abalan  and
H. Verdoux
F. Sorbara
Affiliation:
Department of Psychiatry, University Victor Segalen Bordeaux 2, France Hôpital Charles Perrens, Bordeaux, France
F. Liraud
Affiliation:
Department of Psychiatry, University Victor Segalen Bordeaux 2, France Hôpital Charles Perrens, Bordeaux, France
F. Assens
Affiliation:
Hôpital Charles Perrens, Bordeaux, France
F. Abalan
Affiliation:
Hôpital Charles Perrens, Bordeaux, France
H. Verdoux*
Affiliation:
Department of Psychiatry, University Victor Segalen Bordeaux 2, France Hôpital Charles Perrens, Bordeaux, France
*
*E-mail address: Address: University Department of Psychiatry, Hôpital Charles Perrens, 121, rue de la Béchade, 33076 Bordeaux cedex, France. helene.verdoux@ipso.u-bordeaux2.fr
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Abstract

Objective

To examine the impact of alcohol and substance use on the early course of psychosis.

Methods: First-admitted subjects with psychosis (n = 58) were assessed at 6-month intervals over a 2-year follow-up. Information on substance and alcohol misuse and clinical and social outcome was collected using multiple sources of information.

Results

After adjustment for potential confounding factors, subjects with persistent substance misuse over the follow-up were at increased risk of readmission (OR = 3.1; 95%CI = 1.0-9.4; P = 0.05), of presenting with psychotic symptoms (OR = 4.3; 95%CI = 1.0-18.1; P = 0.04), and with a non-continuous course of illness (OR = 11; 95%CI = 1-122; P = 0.05). No significant association was found between substance misuse and social outcome, or between alcohol misuse and clinical and social outcome.

Conclusions

Persistent substance misuse after a first admission for psychosis has a deleterious impact on clinical outcome. Early identification and treatment of substance use is essential in the care of subjects with incipient psychosis.

Keywords

PsychosisFirst episodeSubstance useOutcome
Type
Short communication
Information
European Psychiatry , Volume 18 , Issue 3 , May 2003 , pp. 133 - 136
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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