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Tetanus antitoxin titration by haemagglutination at a low level of test

Published online by Cambridge University Press:  15 May 2009

A. J. Fulthorpe
A. J. Fulthorpe
Affiliation:
The Wellcome Research Laboratories, (Biological Division), Beckenham, Kent
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An investigation has been made of methods of estimating the antitoxin content of small samples of human sera by haemagglutination procedures.

The direct agglutination test appears to be satisfactory when dealing with groups of sera, but was unreliable for testing individual sera.

The discrepancies observed in the direct agglutination test were greatly reduced by adopting an agglutination inhibition test at the LA/100 level of test.

The difference in agglutinating capacity of both avid and non-avid sera per in vivo unit of antitoxin did not appear to be related to avidity.

Information

Type
Research Article
Information
Journal of Hygiene , Volume 56 , Issue 2 , June 1958 , pp. 183 - 189
Copyright
Copyright © Cambridge University Press 1958

References

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