Hostname: page-component-54dcc4c588-xh45t Total loading time: 0 Render date: 2025-10-01T23:55:05.455Z Has data issue: false hasContentIssue false
  • English
  • Français

Experimental study of a further attenuated live measles vaccine of the Sugiyama strain in Iran

Published online by Cambridge University Press:  15 May 2009

H. Mirchamsy ,
A. Shafyi ,
M. R. Rafyi ,
S. Bahrami ,
P. Nazari  and
S. Fatemie
H. Mirchamsy
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
A. Shafyi
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
M. R. Rafyi
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
S. Bahrami
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
P. Nazari
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
S. Fatemie
Affiliation:
State Razi Institute, P.O. Box 656-Tehran, Iran
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

After encouraging results of the mass vaccination programme in Iran, in which 5 million children in rural areas were vaccinated with the Japanese Sugiyama strain at its 82nd passage in baby calf kidney, and a progressive decrease in the incidence of measles as well as a reduction of excessive infant mortality, a further attenuated vaccine, produced with the same strain, cloned in Japan, was compared in a field trial with the parent vaccine. The new strain caused fewer reactions than the original strain. Seroconversion with a geometric mean antibody titre of 6·1 was observed in 95% of susceptible children.

Information

Type
Research Article
Information
Journal of Hygiene , Volume 72 , Issue 2 , April 1974 , pp. 273 - 279
Copyright
Copyright © Cambridge University Press 1974

References

REFERENCES

Bolotovsky, V. M. & Zetilova, L. P. (1968). Comparative study of the reaction-causing properties and the immunological and epidemiological effectiveness of Leningrad-16 and Schwarz live measles vaccines. Bulletin of the World Health Organization 39, 293–8.Google Scholar
Chumakov, M. P., Vorosilova, M. K., Gracev, V. P., Dzagurov, S. G. & Sineak, K. M. (1967). Le vaccin vivant antirougeoleux de la souche très attenuée E.Sch.Ch. (Edmonston-Schwarz-Chumakov) preparé par l'institut de poliomyelite et d'Encephalites de l'Union Soviétique. Archives Roumaines de Pathologie Expérimental et de Microbiologie 27, 17–33.Google Scholar
Makino, S., Sasaki, K., Nakamura, N., Nakagawa, M., Kasahara, S., Mizunoe, K., Hashimoto, T., Ehihara, T., Nakazawa, S., Oka, H., Sato, H., Watanabe, O., Niino, K., Koga, F., Onuma, M., Kagami, K., Kimura, M., Ishiguro, Y., Yoshida, Z. & Fugii, H. (1973). Field trial with a further attenuated live measles virus vaccine. Japanese Journal of Microbiology 17, 75–9.CrossRefGoogle ScholarPubMed
Manteghi, A. (1971). The epidemiological survey of measles in Iran following mass vaccination. Ministry of Health Report 49, 1–49.Google Scholar
Matumoto, M., Mutai, M., Saburi, Y., Fujii, R., Minamitani, M. & Nakamura, K. (1962). Live measles virus vaccine: clinical trial of vaccine prepared from a variant of the sugiyama strain adapted to bovine kidney cells. Japanese Journal of Experimental Medicine 32, 433–48.Google ScholarPubMed
Mirchamsy, H., Nazari, F., Stellman, C. & Esterabady, H. (1968). The use of dried blood absorbed on filter paper lor the evaluation of diphtheria and tetanus antitoxins in mass surveys. Bulletin of the World Health Organization, 38, 665–71.Google Scholar
Mirchamsy, H., Shafyi, A., Bassli, Y., Bahrami, S. & Nazari, F. (1970). A comparative study of two live measles vaccines in Iran. Journal of Hygiene 68, 101–10.CrossRefGoogle ScholarPubMed
Mirchamsy, H., Shafyi, A., Bahrami, S., Nazari, P., Mirzadeh, M. & Bassali, Y. (1971). Mass immunization of children in Iran with live attenuated Sugiyama measles virus adapted to calf kidney cell culture. Japanese Journal of Experimental Medicine 41, 39–48.Google Scholar
Mirchamsy, H., Razavi, J. & Ahourai, P. (1972). Pathogenesis of vaccine strains of measles virus in suckling hamsters. Acta Virologica 16, 77–9.Google ScholarPubMed
Myamura, K., Yoshizawa, S., Tania, T., Sakai, K., Hashizume, S., Okuni, H., Kawana, R. & Kimura, M. (1971). Further attenuated measles virus strain Sugiyama, having lower ceiling temperature, derived from Sugiyama original strain by elution from aluminum phosphate and limiting dilution of the eluate. 19th Annual Meeting of the Society of Japanese Virologists.Google Scholar
Okuno, Y., Ueda, S., Kurimura, T., Suzuki, N., Yamanishi, K., Baba, K., Takahashi, M., Konobe, T., Sasada, T., Onishi, K. & Takaku, K. (1971). Studies on further attenuated. live measles vaccine. VII. Development and evaluation of CAM-70 measles virus vaccine. Biken Journal 14, 253–8.Google ScholarPubMed
Shishido, A. (1969). A field trial of further attenuated live measles virus vaccines in Japan–1968. Japanese Journal of Medical Science and Biology 22, 191–200.Google Scholar