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The evaluation of a live salmonella vaccine in mice and chickens

Published online by Cambridge University Press:  15 May 2009

V. A. Knivett  and
W. K. Stevens
V. A. Knivett
Affiliation:
Twyford Laboratories Ltd., Twyford Abbey Road, London, N.W.10
W. K. Stevens
Affiliation:
Twyford Laboratories Ltd., Twyford Abbey Road, London, N.W.10
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Mice vaccinated with a live attenuated strain of Salmonella dublin were protected against heavy challenge infections of S. dublin, S. typhimurium, S. choleraesuis and S. anatum. Oral and subcutaneous vaccination were equally effective. When day-old chicks were orally vaccinated and subsequently challenged with S. typhimurium, the growth of the challenge organism was considerably reduced or eliminated from the livers of the vaccinated chicks whereas most of the non-vaccinated were heavily infected. Field trials with vaccinated day-old chicks showed that they suffered no setbacks in growth, stress, loss of appetite or adverse side effects.

Information

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 2 , June 1971 , pp. 233 - 245
Copyright
Copyright © Cambridge University Press 1971

References

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