This study of over 1,000 adolescents focused on common and distinctive correlates of foursubgroups—no problem, depressed only, heavy drinking only, and mixed (depressed andheavy drinking). Correlates were evaluated from the domains of personal dispositions (e.g.,temperament), interpersonal relations (e.g., parent and peer), stressful life events, and otherproblem behaviors (e.g., delinquency, substance use). The no-problem subgroup differed fromthe other three subgroups in the direction of healthier functioning on almost all measures. Themixed subgroup reported the most pervasive, low levels of functioning, with the highest levels ofchildhood externalizing problems and stressful life events, the lowest levels of family socialsupport, and high levels of delinquency and substance use. The depressed-only subgroup reporteda more internalized pattern characterized by childhood avoidance problems, a difficulttemperament (e.g., inflexibility, withdrawal, low task orientation), interpersonal stressors, andpoor coping strategies. The heavy-drinking-only subgroup was characterized by higher drinkinglevels by primary caregivers and lower levels of family cohesion as reported by primarycaregivers. The 1-year prospective findings were generally consistent with the concurrentfindings in that variables that were associated with transitions toward and away from depressionand heavy drinking were associated with specific transitions (e.g., childhood externalizingproblems were associated with the transition from no problem to heavy drinking).