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Immune abnormalities in Kawasaki disease: prognostic implications and insight into pathogenesis

Published online by Cambridge University Press:  19 August 2008

Karyl S. Barron
Karyl S. Barron*
Affiliation:
Pediatric Rheumatology, Baylor College of Medicine, Houston
*
Dr. Karyl S. Barron, Pediatric Rheumatology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA
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Summary

There are a number of abnormalities of the immune system seen in children with Kawasaki disease that are widely integrated and lead eventually to the inflammatory response seen clinically as fever, rash, arthritis, coronary arteritis, etc. The initiating event remains a mystery, however the cascade of immune responses involves both T and B lymphocytes, lymphokine production, and cell adhesion. Until the etiologic agent(s)/ of Kawasaki disease is identified, therapeutic intervention must be directed at controlling the effects of the abnormal immunoregulation.

Type
The World Forum for Pediatric Cardiology Symposium on Kawasaki Disease
Information
Cardiology in the Young , Volume 1 , Issue 3 , July 1991 , pp. 206 - 211
Copyright
Copyright © Cambridge University Press 1991

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