Hostname: page-component-745bb68f8f-d8cs5 Total loading time: 0 Render date: 2025-01-09T22:51:58.478Z Has data issue: false hasContentIssue false
  • English
  • Français

Reactions of the Immune System in Chronic Degenerative Neurological Diseases

Published online by Cambridge University Press:  18 September 2015

P.L. McGeer ,
E.G. McGeer ,
T. Kawamata ,
T. Yamada  and
H. Akiyama
P.L. McGeer*
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver
E.G. McGeer
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver
T. Kawamata
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver
T. Yamada
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver
H. Akiyama
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver
*
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of B.C., Vancouver, British Columbia, Canada V6T 1W5
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Elements consistent with a cell mediated immune response were identified immunohistochemically in amyotrophic lateral sclerosis (ALS) spinal cord and Alzheimer disease (AD) hippocampus. T helper/inducer and cytotoxic/suppressor lymphocytes were detected in affected tissues in both diseases. In addition, abundant reactive microglia were found expressing the major histocompatibility glycoproteins HLA-A,B,C and HLA-DR, as well as receptors for the Fc chain (Fcyγl), for complement 3 and 4, and for vitronectin. In AD, the complement proteins Clq, C4d, C3d and C5b-9 were found on dystrophic neurites, neuropile threads and some neurofibrillary tangles. In ALS, the only complement proteins identified were C4d and C3d. The integrin ligands vitronectin and ICAM-1 were also identified in affected tissues in both diseases.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S3 , August 1991 , pp. 376 - 379
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

REFERENCES

1.Bjorkman, PJ, Saper, MA, Samraoui, B, et al. Structure of the human class 1 histocompatibility antigen, HLA-A2. Nature 1987; 329: 506–512.Google Scholar
2.Stites, DP, Stobo, JD and Wells, JV. Basic and Clinical Immunology, 6th ed. Norwalk, Appleton & Lange 1987.Google Scholar
3.McGeer, PL, Itagaki, S and McGeer, EG. Expression of the histo-compatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol 1988; 76: 550–557.CrossRefGoogle Scholar
4.Tooyama, I, Kimura, H, Akiyama, H, et al. Reactive microglia express class 1 and class II major histocompatibility complex antigens in Alzheimer disease. Brain Res. 1990; 523: 273–280.CrossRefGoogle Scholar
5.Rogers, J, Luber-Narod, J, Styren, SD, et al. Expression of immune system-associated antigen by cells of the human central nervous system. Relationship to the pathology of Alzheimer’s disease. Neurobiol Aging 1988; 9: 330–349.CrossRefGoogle Scholar
6.Styren, SD, Civin, WH and Rogers, J. Molecular, cellular and patho-logic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer’s disease brain. Exp Neurol 1990; 110: 93–104.CrossRefGoogle Scholar
7.Perlmutter, LS, Barron, E and Chui, HC. Morphologic associationbetween microglia and senile plaque amyloid in Alzheimer’s disease. Neurosci Lett 1990; 199:32–36.CrossRefGoogle Scholar
8.Kawamata, T, Akiyama, H, Yamada, T, et al. Immunological reac-tions in amyotrophic lateral sclerosis brain and spinal cord. Soc Neurosci Abstr 1990; 16: 1344.Google Scholar
9.Lampson, LA, Kushner, PD and Sobel, RA. Major histocompatibility complex antigen expression in the affected tissues in amytrophic lateral sclerosis. Ann Neurol 1990; 28: 365–372.CrossRefGoogle Scholar
10.Itagaki, S, McGeer, PL and Akiyama, H. Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer’s disease brain tissue. Neurosci Lett 1988; 91: 259–264.CrossRefGoogle ScholarPubMed
11.McGeer, PL, Akiyama, H, Itagaki, S, et al. Immune system response in Alzheimer’s disease. Can J Neurol Sci 1989; 16: 516–527.CrossRefGoogle ScholarPubMed
12.Eikelenboom, P, Hack, CE, Rozemuller, JM, et al. Complement acti-vation in amyloid plaques in Alzheimer’s dementia. Virchows Arch (Cell Pathol) 1989; 56: 259–262.CrossRefGoogle Scholar
13.Yamada, T, Akiyama, H and McGeer, PL. Complement-activated oligodendroglia: a new pathogenic entity identified by immunos-taining with antibodies to human complement proteins C3d and C4d. Neurosci Letter 1990; 112: 161–166.CrossRefGoogle ScholarPubMed
14.Ishii, T and Haga, S. Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils of senile plaques. Acta Neuropathol (Berlin) 1976; 20: 372–378.Google Scholar
15.Eikelenboom, P and Stam, FC. Immunoglobulins and complement factors in senile plaques. Acta Neuropathol (Berlin) 1982; 57: 239–242.CrossRefGoogle ScholarPubMed
16.Pestronk, A, Adams, RN, Lawson, L, et al. Serum antibodies to GM1 ganglioside in amyotrophic lateral sclerosis. Neurology 1988; 38: 1457–1461.CrossRefGoogle ScholarPubMed
17.Akiyama, H and McGeer, PL. Brain microglia constitutively express (32 integrins. J Neuroimmunol 1990; 30: 81–93.CrossRefGoogle Scholar
18.Akiyama, H, Kawamata, T, Dedhar, S, et al. Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue. J Neuroimmunol 1991; 32: 19–28.CrossRefGoogle ScholarPubMed