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Environmental Factors in the Etiology of Parkinson's Disease

Published online by Cambridge University Press:  05 January 2016

Caroline M. Tanner ,
Biao Chen ,
Wen-Zhi Wang ,
Man-Ling Peng ,
Zho-Lin Liu ,
Xue-Ling Liang ,
Li Chiung Kao ,
David W. Gilley  and
Bruce S. Schoenberg
Caroline M. Tanner*
Affiliation:
Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
Biao Chen
Affiliation:
Department of Neurology, Sun Yat Sen Medical University, Guongzhou, China
Wen-Zhi Wang
Affiliation:
Beijing Neurosurgical Institute, Beijing, China
Man-Ling Peng
Affiliation:
Beijing Neurosurgical Institute, Beijing, China
Zho-Lin Liu
Affiliation:
Department of Neurology, Sun Yat Sen Medical University, Guongzhou, China
Xue-Ling Liang
Affiliation:
Department of Neurology, Sun Yat Sen Medical University, Guongzhou, China
Li Chiung Kao
Affiliation:
Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
David W. Gilley
Affiliation:
Department of Psychology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
Bruce S. Schoenberg
Affiliation:
Neuroepidemiology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
*
Department of Clinical Neurological Sciences, University Hospital, Saskatoon, Saskatchewan, Canada S7N 0X0
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Abstract:

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Parkinson's disease (PD) has been proposed to result from the interaction of aging and environment in susceptible individuals. Defective metabolism of debrisoquine, inherited as an autosomal recessive, has been associated with this susceptibility. In 35 PD patients and 19 age-matched controls, no significant differences in debrisoquine metabolism were found, although a trend to impaired metabolism was noted in patients with disease onset ≤40. Foci of PD patients were associated with rural living and well water drinking, or rural living coupled with market gardening or wood pulp mills. In a questionnaire survey, patients with PD onset ≤age 47 were significantly more likely to have lived in rural areas and to have drunk well water than those with onset ≥age 54 (p≤0.01). Because of population mobility in North America, a case-control study designed to test environmental, occupational, dietary and other proposed risk factors for PD was conducted in China, where the population is more stationary and the environment more stable. No significant differences in incidences of head trauma, smoking or childhood measles were found between patients and controls.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 14 , Issue S3 , August 1987 , pp. 419 - 423
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

References

REFERENCES

1.Mutch, WJ, Dingwall-Fordyce, I, Downie, AW, et al. Parkinson’s disease in a Scottish city. Brit Med J 1986; 192: 534–536.CrossRefGoogle Scholar
2.Rajput, AH, Offord, KP, Beard, MC, et al. Epidemiology of parkinsonism: Incidence, classification, and mortality. Ann Neurol 1984; 16: 278–282.CrossRefGoogle ScholarPubMed
3.Calne, DB, Langston, JW. Aetiology of Parkinson’s disease. Lancet 1983; 2: 1457’1459.CrossRefGoogle ScholarPubMed
4.Barbeau, A.Etiology of Parkinson’s disease: A research strategy. Can J Neurol Sci 1984; 11: 24–28.CrossRefGoogle ScholarPubMed
5.Gowers, WR.A manual of diseases of the nervous system. American edition. Philadelphia: Blakisten, Son & Co., 1888.CrossRefGoogle Scholar
6.Hart, TS.Paralysis agitans: Some clinical observations based on the study of 219 cases seen at the clinic of Professor Allen Starr, M.. J Nerv Ment Dis 1904; 31: 177–188.CrossRefGoogle Scholar
7.Mjönes, H.Paralysis agitans: A clinical and genetic study. Acta Psychiatr Neurol 1949; 54 (Suppl): 1–94.Google Scholar
8.Kondo, K, Kurland, LT, Schull, WJ. Parkinson’s disease: genetic analysis and evidence of a multifactorial etiology. Mayo Clin Proc 1973; 48: 465–475.Google ScholarPubMed
9.Martin, WE, Young, WI, Anderson, VE. Parkinson’s disease: A genetic study. Brain 1973; 96: 495–506.CrossRefGoogle ScholarPubMed
10.Myrianthopoulos, NC, Waldrop, IN, Vincent, BL. A repeat study of hereditary predisposition in drug-induced parkinsonism. In: Bar-beau, A, Brunett, JR, eds. Progress in Neurogenetics. Amsterdam, Excerpta Medica 1969; 486–491.Google Scholar
11.Barbeau, A, Pourcher, E. New data on the genetics of Parkinson’s disease. Can J Neurol Sci 1981; 9: 53–60.CrossRefGoogle Scholar
12.Barbeau, A, Roy, M.Familial subsets in idiopathic Parkinson’s disease. Can J Neurol Sci 1984; 11: 144–150.CrossRefGoogle ScholarPubMed
13.Alonso, ME, Otero, E, D’Regules, R, et al. Parkinson’s disease: A genetic study. Can J Neurol Sci 1986; 13: 248–251.CrossRefGoogle ScholarPubMed
14.Duvoisin, RC, Gearing, IR, Schweitzer, MR, et al. A family study of Parkinsonism. In: Barbeau, A, Brunette, JR, eds. Progress in Neurogenetics. Excerpta Medica Foundation 1969; 492–496.Google Scholar
15.Ward, CD, Duvoisin, RC, Ince, SE, et al. Parkinson’s disease in 65 pairs of twins and in a set of quadruplets. Neurology 1983; 33: 815–24.CrossRefGoogle Scholar
16.Marttila, RJ, Kaprio, J, Koskenvuo, M, et al. Finnish Parkinson’s disease twin studv: Preliminary results. Upsala J Med Sci 1986; (Supp 43): 93.Google Scholar
17.Rinne, UK. Recent Advances in Research on Parkinsonism. In: Marttila, RJ, ed. Proceedings of the 22nd Scandinavian Congress of Neurology. Acta Neurologica Scandinavica 1978; (Suppl 67): 77–113.Google Scholar
18.Strang, RR. The ABO blood-group distribution of 450 Swedish patients with Parkinson’s disease. Neurology 1966; 16: 1051–1052.CrossRefGoogle ScholarPubMed
19.Barbeau, A, Roy, M, Paris, S, et al. Ecogenetics of Parkinson’s disease: 4-hydroxylation of debrisoquine. Lancet 1985; 2: 1213–1215.CrossRefGoogle ScholarPubMed
20.Cornelia, CL, Tanner, CM, Goetz, CG, et al. Debrisoquine metabolism in Parkinson’s disease. Neurology 1987; (suppl 1): 261–262.Google Scholar
21.Mena, I, Marin, O, Fuenzalida, S.Chronic manganese poisoning: Clinical picture and manganese turnover. Neurology 1976; 17: 128–136.CrossRefGoogle Scholar
22.Emara, AM.Chronic manganese poisoning in the dry battery industry. Brit J Indust Med 1971; 28: 78–84.Google ScholarPubMed
23.Garruto, RM, Gajdusek, C.Factors provoking the high incidence of amyotrophic lateral sclerosis and parkinsonism-dementia of Guam: Deposition and distribution of toxic metals and essential minerals in the central nervous system. In: Gottfries, CG, ed. Normal Aging, Alzheimer’s Disease and Senile Dementia. Aspects of Etiology, Pathogenesis, Diagnosis and Treatment. Editions de l’Université de Bruxelles, Bruxelles 1985; 69–81.Google Scholar
24.Chen, K, Chase, TN.Parkinsonism-dementia. In: Vinken, P, Bruyn, G, Klawans, HL, eds. Handbook of Clinical Neurology, Vol 49, Chapter 8. Elsevier Science, Amsterdam. 1986: 167–183.Google Scholar
25.Langston, JW, Ballard, P, Tetrud, JW, et al. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1982; 219: 979–980.CrossRefGoogle Scholar
26.Tetrud, JW, Langston, JW. Early parkinsonism in humans due to MPTP exposure. Neurology 1986; 36 (Suppl): 308.Google Scholar
27.Burns, RS, Phillips, JM, Chiueh, CC, et al. The MPTP-treated monkey model of Parkinson’s disease. In: Markey, SP, Castagnoli, N, Trevor, AJ, Kopin, IJ, eds. MPTP: A neurotoxin producing a parkinsonian syndrome. Academic Press, Orlando, 1986; 23–42.Google Scholar
28.Forno, LS, Langston, JW, DeLanney, LE, et al. Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann Neurol 1986; 20: 449–455.CrossRefGoogle ScholarPubMed
29.Langston, JW, Ballard, PA.Parkinson’s disease in a chemist working with 1 -methyl-4-phenyl-1,2,5,6-tetrahydropyridine. New Engl J Med 1983; 309: 310.Google Scholar
30.Solomon, H, D’Amato, RJ. Predicting Parkinson’s disease. Nature 1985; 317: 198–199.Google Scholar
31.Rajput, AH, Uitti, RJ, Stern, W, et al. Early onset of Parkinson’s disease in Saskatchewan - environmental considerations for etiology. Can J Neurol Sci 1986; 13: 312–316.CrossRefGoogle ScholarPubMed
32.Barbeau, A, Roy, M.Genetic susceptibility, environmental factors and Parkinson’s disease. VIII International Symposium on Parkinson’s Disease; New York, 1985; 13.Google Scholar
33.Aquilonius, SM, Hartvig, P.Utilization of antiparkinson drugs in Sweden. Upsala J Med Sci 1986; (Supp 43): 93.Google Scholar
34.Tanner, CM.Influence of environmental factors on the onset of Parkinson’s disease (PD). Neurology 1986; 36 (Suppl): 215.Google Scholar
35.Charcot, JM.Lectures on the Diseases of the Nervous system. Vol 1 (translated by Sigeran, G.). London: The New Sydenham Society, 1887.Google Scholar
36.Gibberd, FB, Simmonds, JP. Neurological disease in ex-far-east prisoners of war. Lancet 1980; 2: 135–137.CrossRefGoogle ScholarPubMed
37.Li, S, Schoenberg, BS, Wang, C, et al. A prevalence survey of Parkinson’s disease and other mo vement disorders in the People’s Republic of China. Arch Neurol 1985; 42: 655–657.CrossRefGoogle Scholar
38.Schlesselman, JJ, Stolley, PD. Case-control studies: Design, conduct, analysis. New York: Oxford University Press, 1982.Google Scholar
39.Godwin-Austen, RB, Lee, PN, Marmot, MG, et al. Smoking and Parkinson’s disease. J Neurol Neurosurg Psychiat 1982; 45: 577–581.CrossRefGoogle ScholarPubMed
40.Baumann, RJ, Jameson, HD, McKean, HE, et al. Cigarette smoking and Parkinson’s disease: 1. A comparison of cases with matched neighbors. Neurology 1980; 30: 839–843.CrossRefGoogle ScholarPubMed
41.Bharucha, NE, Stokes, L, Schoenberg, BS, et al. A case-control study of twin pairs discordant for Parkinson’s disease: A search for environmental risk factors. Neurology 1986; 36: 284–288.CrossRefGoogle ScholarPubMed
42.Rajput, AH.Epidemiology of Parkinson’s disease. Can J Neurol Sci 1984; 11: 156–159.CrossRefGoogle ScholarPubMed
43.Golbe, LI, Cody, RA, Duvoisin, RC.Smoking and Parkinson’s disease: Search for dose-response relationship. Arch Neurol 1986; 43: 774–778.CrossRefGoogle ScholarPubMed
44.Moore, G.Influenzaand Parkinson’s disease. Public Health Reports 1977; 92: 79.Google Scholar
45.Marttila, RJ, Halonen, P, Rinne, UK.Influenza virus antibodies in parkinsonism. Arch Neurol 1977; 34: 99–100.CrossRefGoogle ScholarPubMed
46.Sasco, AJ, Paffenbarger, RS.Measles infection and Parkinson’s disease. Am J Epidemiol 1985; 133: 1017–1031.CrossRefGoogle Scholar
47.Parkinson, J.An essay on the shaking palsy. London: Whittingham & Rowland, 1817.Google Scholar