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Alzheimer's Disease: Environmental Factors and Etiologic Hypotheses

Published online by Cambridge University Press:  18 September 2015

Denyse Gautrin  and
Serge Gauthier
Denyse Gautrin
Affiliation:
McGill Centre for Studies in Aging, McGill University, Montreal INRS - Santé
Serge Gauthier*
Affiliation:
McGill Centre for Studies in Aging, McGill University, Montreal
*
1650 Cedar Ave, Montreal, Quebec, Canada H3G 1A4
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Abstract:

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A review of published reports on conventional and unconventional viruses, aluminum, neurotoxic metals and trace elements, neurotoxins of biological origin and immune systems, suggest that environmental factors, possibly multiple ones, play a significant role in the etiology of Alzheimer's disease. A complex interaction between genetic predisposition to this illness, natural aging processes, environmental factors over a life-time exposure and pathological alterations of the host immune system is proposed.

Résumé:

RÉSUMÉ:

Notre revue des rapports publiés sur les virus conventionnels et non-conventionnels, l'aluminium, les métaux neurotoxiques et éléments rares, les neurotoxines biologiques et les systèmes immunitaires, suggère que des facteurs environnementaux, possiblement multiples, jouent un rôle significatif dans l'étiologie de la maladie d'Alzheimer. Une interaction complexe entre une prédisposition génétique à cette maladie, les mécanismes du vieillissement naturel, les facteurs environmentaux au cours de la vie et des changements pathologiques du système immunitaire de l'hôte est proposée.

Type
Review Article
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 4 , November 1989 , pp. 375 - 387
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

REFERENCES

1. Gajdusek, DC. Unconventional viruses and the origin and disap-pearance of kuru. Science 1977; 197:943–960.CrossRefGoogle ScholarPubMed
2. Masters, CL, Gajdusek, DC, Gibbs, CJ Jr. The familial occurrence of Creutzfeldt-Jakob disease and Alzheimer’s disease. Brain 1981; 104: 535–558.CrossRefGoogle ScholarPubMed
3. Roos, RP. Alzheimer’s disease and the lessons of transmissible virus dementia. In: Mortimer, JA, Shuman, LM, eds. Epidemiology of Dementia. Oxford University Press, New York, 1981; 73–86.Google Scholar
4. Goudsmith, J, Morrow, CH, Asher, DM, Yanagihara, RT, et al. Evidence for and against transmissibility of Alzheimer disease. Neurology 1980; 30: 945–950.CrossRefGoogle Scholar
5. De Boni, V, Crapper, DR. Paired helical filaments of the Alzheimer type in cultured neurons. Nature 1978; 271: 566–568.CrossRefGoogle Scholar
6. Prusiner, SB, et al. Some speculations about prions, amyloid and Alzheimer’s disease. New Engl J Med 1984; 310: 661–663.CrossRefGoogle ScholarPubMed
7. McGeer, PL, McGeer, EG, Kamo, H, et al. Positron emission tomography and the possible origins of cytopathology in Alzheimer’s disease. Prog Neuropsych Biol Psych 1986; 10: 501–518.CrossRefGoogle ScholarPubMed
8. Esiri, MM. Typical and atypical viruses in the aetiology of senile dementia of the Alzheimer type. Interdisciplinary Topics Gerontol 1988; 25: 119–139.CrossRefGoogle Scholar
9. Amaducci, LA, Fratiglioni, L, Rocca, WA, et al. Risk factors for clinically diagnosed Alzheimer’s disease: a case control study of an Italian population. Neurology 1986; 36: 922–931.CrossRefGoogle ScholarPubMed
10. French, RL, Schuman, LM, Mortimer, JA, Hutton, JT, Boatman, RA, Christians, B. A case control study of dementia of the Alzheimer type. Am J Epi 1985; 121:414–421.CrossRefGoogle ScholarPubMed
11. Heyman, A, Wilkinson, WE, Stafford, JA, Helins, MJ, Sigmon, AH, Weinber, T. Alzheimer’s disease: a study of epidemiological aspects. Ann Neurol 1984; 15: 335–41.CrossRefGoogle ScholarPubMed
12. Chandra, V, Philipose, RN, Bell, PA, Lazaroff, A, Schoenberg, BS. Case control study of late onset “probable Alzheimer’s disease”. Neurology 1987; 37: 1295–1300.CrossRefGoogle ScholarPubMed
13. Shalat, SL, Seltzer, B, Pidcock, C, Baker, EL. Risk factors for Alzheimer’s disease: a case control study. Neurology 1987; 37: 1630–1633.CrossRefGoogle ScholarPubMed
14. Lycke, E, Norsby, R, Roos, B. A serological study on mentally ill patients with particular reference to the prevalence of herpes virus infections. Br J Psych 1974; 124: 273–9.CrossRefGoogle Scholar
15. Lord, A, Sutton, RNP, Baker, AA, Hussein, SMA. Serological studies in the elderly. Age and Ageing 1978; 7: 116–22.CrossRefGoogle ScholarPubMed
16. Whalley, LJ, Urbaniak, SJ, Darg, C, et al. Histocompatibility anti-gens and antibodies to viral and other antigens in Alzheimer pre-senile dementia. Acta Psychr Scand 1980; 61: 1–7.CrossRefGoogle Scholar
17. Renvoize, EB, Wad, LO, Hambling, MH. A sero-epidemiological study of conventional infectious agents in Alzheimer’s disease. Age and Ageing 1987; 16:311–314.CrossRefGoogle ScholarPubMed
18. McKhann, G, Drachman, D, Folstein, M, et al. Report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology 1984; 34: 939–944.CrossRefGoogle ScholarPubMed
19. Pogo, BGT, Casals, J, Elizan, TS. A study of viral genomes and antigens in brains of patients with Alzheimer’s disease. Brain 1987; 110: 907–915.CrossRefGoogle ScholarPubMed
20. Mann, MA, Yates, PO, Davies, JS, Hawkes, J. Viruses, parkinsonism and Alzheimer’s disease. J Neurol Neurosurg and Psych 1981; 44: 651.CrossRefGoogle ScholarPubMed
21. Sequiera, LW, Jennings, LC, Carasco, LH, Lord, M, Curry, A, Sutton, RNP. Detection of herpes simplex viral genome in brain tissue. Lancet 1979;2:609–12.CrossRefGoogle ScholarPubMed
22. Taylor, GR, Crow, TJ, Markakis, DA, Lofthouse, R, Neeley, S, Carter, GI. Herpes simplex virus and Alzheimer’s disease: a search for virus DNA by spot hybridization. J Neurol Neurosurg and Psych 1984; 47: 1061–1065.CrossRefGoogle Scholar
23. Walker, D, O’Kusky, JR, McGeer, PL, McGeer, EG. Hybridization analyses of Alzheimer’s brains for herpes virus DNA. Society for Neuroscience Abstracts, 1987; 13: 13–27.Google Scholar
24. Esiri, MM. Viruses and Alzheimer’s disease. J Neurol Neurosurg and Psych 1982; 45:759.CrossRefGoogle ScholarPubMed
25. Ball, MJ. Limbic predilection in Alzheimer’s dementia: is reacti-vated herpes virus involved? Can J Neurol Sci 1982; 9: 303–306.CrossRefGoogle Scholar
26. Merz, PA, Somerville, RA, Wisniewski, HM. Abnormal fibrils from scrapie-infected brain. Acta Neuropathol (Berl) 1981; 54: 63–74.CrossRefGoogle ScholarPubMed
27. Wisniewski, HM, Moretz, RC, Lossinsky, AS. Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent. Ann Neurol 1981; 10: 517–522.CrossRefGoogle ScholarPubMed
28. Baker, HF, Ridley, RM, Crow, TJ. Experimental transmission of an autosomal dominant spongiform encephalopathy: does the infectious agent originate in the human genome? Br Med J 1985; 291: 299–302.CrossRefGoogle ScholarPubMed
29. Greenham, LW, Peacock, DB. Comparison of survival times of mice inoculated with brain tissue from various neurological diseases. Ann Neurol 1985; 17: 206–209.CrossRefGoogle ScholarPubMed
30. Manuelidis, E, de Figueiredo, IM, Kim, JE. Transmission studies from blood of Alzheimer’s disease patients and healthy relatives. Proc Natl Acad Sci 1988; 85: 4898–4901.CrossRefGoogle ScholarPubMed
31. Crapper, DR, Daltor, AJ. Aluminum induced neurofibrillary degen-eration, brain electrical activity and alterations in acquisition and retention. Physiol Behav 1973; 10: 935.CrossRefGoogle Scholar
32. Crapper, DR, Krishnan, SS, Quittkat, S. Aluminum neurofibrillary degeneration in Alzheimer’s disease. Brain 1976; 99: 67–80.CrossRefGoogle Scholar
33. Ward, WI, Mason, JA. Neutron activation analysis for identifying elemental status in Alzheimer’s disease. J Radional Nucl Chem 1987; 11:515–526.CrossRefGoogle Scholar
34. Candy, JM, Klinowski, RA, Perry, EK. Aluminosilicates and senile plaques formation in Alzheimer’s disease. Lancet 1986; 1: 353–356.Google ScholarPubMed
35. Trapp, GA, Milner, GD, Zimmerman, RL, et al. Aluminum levels in brain in Alzheimer’s disease. Biol Psychiatry 1978; 13: 709.Google ScholarPubMed
36. Perl, DP, Brody, AR. Alzheimer’s disease: spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science 1980; 208; 297.CrossRefGoogle ScholarPubMed
37. Duckett, S, Galle, P.C.R. Mise en évidence de l’aluminum dans les plaques séniles de la maladie d’Alzheimer: étude à la microsonde de Castaing. Acad Sci [D] (Paris) 1976; 282(4): 293–5.Google Scholar
38. Masters, CL, Multhaup, G, Simons, G, et al. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer’s disease contain the same protein as the amyloid of plaque cores and blood vessels. Embo J 1985; 4: 27–57.CrossRefGoogle ScholarPubMed
39. Krishnan, SS, McLachlan, DR, Krishnan, B, et al. Aluminum toxicity to the brain. Sci Tot Environ 1988; 71: 59–74.CrossRefGoogle ScholarPubMed
40. Garruto, RM, Fukatsu, R, Yanagihara, R, et al. Imaging of calcium and aluminum in neurofibrillary tangles-bearing neurons in parkinsonism dementia of Guam. Proc Natl Acad Sci USA 1984; 81: 1875–1879.CrossRefGoogle Scholar
41. Gardner, MJ, Winter, PD, Barker, DJP. Atlas of mortality from selected diseases in England and Wales 1968–78. Wiley, Chichester, 1984: 62–63.Google Scholar
42. Vogt, T. Water quality and health: study of a possible relation between aluminum in drinking water and dementia. Sosiale og. Okonomiske Studier no. 61, 1986; Norwegian Government.Google Scholar
43. Nodberg, GF, Goyer, KA, Clarkson, TW. Impact of effects of acid precipitation in toxicity and metals. Environ Health Persp 1985; 63: 169–180.CrossRefGoogle Scholar
44. Alfrey, AC, LeGendre, GR, Kaehney, WD. Dialysis encephalopathy syndrome: possible aluminum intoxication. N Engl J Med 1976; 294: 184.CrossRefGoogle ScholarPubMed
45. Elliott, HL, MacDougall, AI. Aluminum studies in dialysis encephalopathy. Proc Eur Dial Transplant Assoc 1978; 15: 157.Google ScholarPubMed
46. Schreeder, MT, Favero, MS, Hughes, JR, et al. Dialysis encephalopathy and aluminum exposure: an epidemiological analysis. J Chron Dis 1983; 36(8): 581–593.CrossRefGoogle Scholar
47. Ward, M. Dialysis dementia and bone disease in Great Britain. Symp dialysis dementia and aluminum toxicity, Chicago, 1978.Google Scholar
48. Galle, P, Berry, JP, Duckett, S. Electron microprobe ultrastructural localization of aluminum in rat brain. Arch Neuropathol 1980; 49: 245.CrossRefGoogle ScholarPubMed
49. Buge, A. Encéphalopathie prolongée et reversible chez un dialysé chronique. Responsabilité probable des sels d’aluminium. Nouv Presse Med 1978; 7: 2053.Google Scholar
50. Scholtz, CL, Swash, M, Gray, A, et al. Neurofibrillary neuronal degeneration in dialysis dementia: a feature of aluminum toxicity. Clin Neuropathol 1987; 6(3): 93–97.Google ScholarPubMed
51. McLauglin, AIG, Kazantzis, G, King, E, Teare, D, Porter, RJ, Owen, R. Pulmonary fibrosis and encephalopathy associated with the inhalation of aluminum dust. Br J Ind Med 1962; 19: 253.Google Scholar
52. Kobayashi, S, Hirota, N, Saito, K, Utsuyama, M. Aluminum accu-mulation in tangle-bearing neurons of Alzheimer’s disease with Balint’s syndrome in a long term aluminum refiner. Acta Neuropathol (Berl) 1987; 74: 47–52.CrossRefGoogle Scholar
53. Yokel, RA. Hair as an indicator of excessive aluminum exposure. Clin Chem 1982; 28/4: 662–665.CrossRefGoogle ScholarPubMed
54. Cornelis, R. Variability in reported plasma Al-concentrations. In: CEC Luxembourg 1982.Google Scholar
55. Versiek, J, Cornelis, R. Measuring aluminum levels. New Eng J Med 1980; 302(8): 468.Google Scholar
56. Kaehny, WD, Hegg, AP, Alfrey, AC. Gastrointestinal absorptions of aluminum from aluminum-containing antacids. N Engl J Med 1977; 296: 389–94.CrossRefGoogle ScholarPubMed
57. Sjogren, B, Lundberg, I, Lidums, V. Aluminum in the blood and urine of industrially exposed workers. Br J Ind Med 1983; 40: 301–304.Google ScholarPubMed
58. Mussi, L, Calzaferri, G, Buratti, M, Alessio, L. Behaviour of plasma and urinary aluminum levels in occupationally exposed subjects. Int Arch Occup Environ Health 1984; 54: 115–161.CrossRefGoogle ScholarPubMed
59. Sjogren, B, Lidums, V, Hakansson, M, Heldstrom, L. Exposure and urinary excretion of aluminum during welding. Scand J Work Environ Health 1985; 11: 39–43.CrossRefGoogle ScholarPubMed
60. Sjogren, B, Elinder, CG, Lidums, V, Chang, G. Uptake and urinary excretion of aluminum among workers. Int Arch Occup Environ Health 1988; 60: 77–79.CrossRefGoogle Scholar
61. Shore, D, Wyatt, JW. Aluminum and Alzheimer’s disease. J Nerv Ment Dis 1983; 171:553–558.CrossRefGoogle ScholarPubMed
62. Cremer, JE. Biochemical studies on the toxicity of tetraethyl lead and other organo-Iead compounds. Br J Ind Med 1959; 16: 191–9.Google ScholarPubMed
63. Cassells, DAK, Dodds, EC. Tetraethyl lead poisoning. Br J Med 1946; 2: 681–5.CrossRefGoogle ScholarPubMed
64. Seawright, AA, Brown, AW, Aldridge, WW, Verschoyle, RD, Street, BW. In: Holmstedt, B, Lawreys, R, Mercier, M, Robertford, M, eds. Mechanisms of toxicity and hazard evaluation. Elsevier/Worth Holland Biomedical Press, Amsterdam, 1980; 71.Google Scholar
65. Niklowitz, WJ. Neurofibrillary changes after acute experimental lead poisoning. Neurology 1975; 25: 927–934.CrossRefGoogle ScholarPubMed
66. Niklowitz, WJ, Mandybur, TI. Neurofibrillary changes following childhood lead encephalopathy: case report. J Neuropathol Exp Neurol 1975; 34:445–455.CrossRefGoogle Scholar
67. Walsh, TJ, DeHaven, DL. Neurotoxicity of alkyltins. In: Bondy, SC, Prasad, KN, eds. Metal neurotoxicity. CRC Press, Inc. 1988.Google Scholar
68. Bouldin, TH, Goines, ND, Bagnell, CR, et al. Pathogenesis of trimethyltin neuronal toxicity: Ultrastructural and cytochemical observations. Am J Pathol 1981; 104: 237.Google ScholarPubMed
69. Chang, LW, Tiemeyer, TM, Wenger, GR, et al. Neuropathology of trimethyltin intoxication II. Electron microscopy of the hippocampus. Environ Res 1982; 29: 445.CrossRefGoogle ScholarPubMed
70. LeQuesne, PM. Metal induced diseases of the nervous system. Br J Hosp Med 1982; 534–538.Google Scholar
71. Markesbery, WR, Ehmann, WD, Hossain, T, Alauddin, M. Brain manganese concentrations in human aging and Alzheimer’s disease. Neurotoxicology 1984; 5: 49–57.Google ScholarPubMed
72. Banta, RG, Markesbery, WR. Elevated manganese levels associated with dementia and extrapyramidal signs. Neurology 1977; 27: 213–216.Google ScholarPubMed
73. Cotzias, GC, Horiuchi, K, Fuenzalida, S, Mena, I, Chronic manganese poisoning: clearance of tissue manganese with persistence of the neurologic picture. Neurology 1968; 18: 376–382 Google Scholar
74. Hunter, D, Bomford, RR, Russell, DS. Poisoning by methylmercury compounds. Q J Med 1940; 9: 193–213.Google Scholar
75. Clarkson, TW, Smith, JC, Marsh, DO, Turner, MD. A review of dose-response relationships resulting from human exposure to methylmercury compounds. In: Krenkel, PA, ed. Heavy metals in the aquatic environment. Oxford: Pergamon Press, 1975; 112.Google Scholar
76. LeQuesne, PM. Toxic substances and the nervous system: the role of clinical observation. J Neurol Neurosurg and Psych 1981; 44: 1–8.CrossRefGoogle Scholar
77. Ehmann, WD, Markesbery, WR, Alauddin, M, Hossain, T, Brubaker, EH. Brain trace elements in Alzheimer’s disease. Neurotoxicology 1986; 7: 197–206.Google ScholarPubMed
78. Thompson, CM, Markesbury, WR, Ehmann, WD, Mao, YX, Vance, DE. Regional brain trace element studies in Alzheimer’s disease. Neurotoxicology 1988; 9: 1–8.Google ScholarPubMed
79. Vance, DE, Ehmann, WD, Markesbery, WR. Trace elements imbal-ances in hair and nails of Alzheimer’s disease patients. Neurotoxicology 1988; 2: 197–208.Google Scholar
80. Clarkson, TW. Metal toxicity in the central nervous system. Environ Health Persp 1987; 75: 59–64.CrossRefGoogle ScholarPubMed
81. Choi, BH, Lapham, LW, Amin-Zaki, L, Saleem, T. Abnormal neu-ronal migration, deranged cerebral cortical organizations and diffuse white matter astrocytosis of human fetal brain: a major effect of methyl mercury poisoning in vitro. J Neuropath Exp Neurol 1978; 37: 719–733.CrossRefGoogle Scholar
82. Burnet, FM. A possible role of zinc in the pathology of dementia. Lancet 1981; 1: 186–188.CrossRefGoogle ScholarPubMed
83. Markesbery, WR, Ehmann, WD. Trace elements in dementing dis-orders. In: Montey, JE, Sterman, MB, Walsh, JM, eds. Nutritional modulation of neural function. San Diego Academic Press, 1988; 179–190.CrossRefGoogle Scholar
84. Wallwork, JC. Zinc and the central nervous system. Progress in food and nutrition. Science 1987; 11: 203–247.Google Scholar
85. Martyn, CN. Neurobiological clues from environmental neurotoxins. Brit M J 1987; 295: 346–347.CrossRefGoogle Scholar
86. Reed, DM, Brody, JA. Amyotrophic lateral sclerosis and parkin-sonism dementia on Guam. Am J Epidemiol 1975; 101: 287–301.CrossRefGoogle Scholar
87. Langston, JW, Ballard, P. Parkinsonism induced by MPTP: impli-cations for treatment and the pathogenesis of Parkinson’s disease. Can J Neurol Sci; 1984; 11 (Suppl): 160–105.CrossRefGoogle Scholar
88. Teitelbaum, JS, Zatorre, RJ, Carpenter, S, et al. Neurological seque-lae of domoic acid intoxication due to ingestion of mussels from Prince Edward Island. Submitted for publication, 1988.Google Scholar
89. Soininen, H, Heinonen, OP. Clinical and etiological aspects of senile dementia. Env Neurol 1982; 21: 401–410.Google ScholarPubMed
90. Heston, L, Mastri, AR, Anderson, E, White, J. Dementia of the Alzheimer’s type: clinical genetics, natural history and associated conditions. Arch Gen Psychiatry 1981; 38: 1085–1090.CrossRefGoogle ScholarPubMed
91. Heyman, A, Wilkinson, WE, Horwitz, BJ, et al. Alzheimer’s dis-ease: genetic aspects and associated clinical disorders. Ann Neurol 1983; 14: 507–515.CrossRefGoogle Scholar
92. Bharucha, NE, Schoenberg, BS, Kokmen, E. Dementia of Alzheimer’s type (DAT): a case–control study of association with medical conditions and surgical procedures. Neurology (NY) 1983; 33: 85.Google Scholar
93. Tavolato, B, Argentiero, V. Immunological indices in presenile Alzheimer’s disease. J Neurol Sci 1980; 46: 325–331.CrossRefGoogle ScholarPubMed
94. Clemenceau, S, Foncin, JF, Muller, JY, et al. Génétique. Absence de liaison entre la maladie d’Alzheimer et les marqueurs du complement. C R Acad Sci (Paris) 1986; T303, no. 5.Google Scholar
95. Singh, VK, Fudenberg, HH. Detection of brain autoantibodies in the serum of patients with Alzheimer’s disease but not Down’s syndrome. Immunol Lett 1986; 12: 277–280.CrossRefGoogle Scholar
96. Skias, D, Baria, M, Reder, AT, et al. Senile dementia of Alzheimer’s type (SDAT): reduced T8+-cell mediated suppressor activity. Neurology 1985; 35: 1635–1638.CrossRefGoogle ScholarPubMed
97. McDonald, SM, Goldstone, AH, Morris, JE, et al. Immunological parameters in the aged and in Alzheimer’s disease. Clin Exp Immunol 1982; 49: 123–128.Google Scholar
98. Watts, HF. Investigations into an immunological component in Alzheimer’s disease. Interdiscip Top Gerontol 1985; 19: 54–61.CrossRefGoogle Scholar
99. Bianchi, C, Bittesini, L, Brollo, A. Asbestos exposure and Alzheimer’s disease. Ital J Neurol Sci 1986; 7: 145–151.CrossRefGoogle Scholar
100. Foncin, JF, Salmon, D, Supino-Viterbo, V, et al. Alzheimer’s prese-nile dementia transmitted in extended kindreds. Rev Neurol (Paris) 1985; 141(3): 194–202.Google Scholar
101. Mohs, RC, Breitner, JCS, Silverman, JM, Davis, KL. Alzheimer’s disease. Morbid risk among first-degree relatives approximates 50% by 90 years of age. Arch Gen Psychiatry 1987; 44: 405–408.CrossRefGoogle ScholarPubMed