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α-Klotho: the hidden link between dietary inflammatory index and accelerated ageing

Published online by Cambridge University Press:  20 September 2024

Ruiqiang Li ,
Baijing Zhou ,
Xueqing Deng ,
Wenbo Tian ,
Yingyue Huang ,
Jiao Wang  and
Lin Xu Open the ORCID record for Lin Xu [Opens in a new window]
Ruiqiang Li
Affiliation:
School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Baijing Zhou
Affiliation:
School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Xueqing Deng
Affiliation:
School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Wenbo Tian
Affiliation:
School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Yingyue Huang
Affiliation:
School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Jiao Wang
Affiliation:
School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Lin Xu*
Affiliation:
School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong Institute of Applied Health Research, University of Birmingham, Birmingham, UK
*
*Corresponding author: Lin Xu, email xulin27@mail.sysu.edu.cn
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Abstract

Recent studies suggest an association between greater dietary inflammatory index (DII) and higher biological ageing. As α-Klotho has been considered as a longevity protein, we examined whether α-Klotho plays a role in the association between DII and ageing. We included 3054 participants from the National Health and Nutrition Examination Survey. The associations of DII with biological and phenotypic age were assessed by multivariable linear regression, and the mediating role of α-Klotho was evaluated by mediation analyses. Participants’ mean age was 58·0 years (sd 11·0), with a median DII score of 1·85 and interquartile range from 0·44 to 2·79. After adjusting for age, sex, race/ethnicity, BMI, education, marital status, poverty income ratio, serum cotinine, alcohol, physical activity, a higher DII was associated with both older biological age and phenotypic age, with per DII score increment being associated with a 1·01-year increase in biological age (1·01 (95 % CI: 1·005, 1·02)) and 1·01-year increase in phenotypic age (1·01 (1·001, 1·02)). Negative associations of DII with α-Klotho (β = –1·01 pg/ml, 95 % CI: –1·02, –1·006) and α-Klotho with biological age (β= –1·07 years, 95 % CI: –1·13, –1·02) and phenotypic age (β= –1·03 years, 95 % CI: –1·05, –1·01) were found. Furthermore, α-Klotho mediated 10·13 % (P < 0·001) and 9·61 % (P < 0·001) of the association of DII with biological and phenotypic age, respectively. Higher DII was associated with older biological and phenotypic age, and the potential detrimental effects could be partly mediated through α-Klotho.

Keywords

Dietary inflammatory indexα-KlothoBiological agePhenotypic age
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 5 , 14 September 2024 , pp. 558 - 564
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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