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Effects of the rs174575 single nucleotide polymorphism in FADS2 on levels of long-chain PUFA: a meta-analysis

Published online by Cambridge University Press:  11 November 2024

Motong Liu Open the ORCID record for Motong Liu [Opens in a new window] ,
Yanyan Wu ,
Song Ni ,
Jiayu Gong ,
Yifei Chen ,
Yuan He ,
Shutong Chen ,
Haitao Yu  and
Lin Xie Open the ORCID record for Lin Xie [Opens in a new window]
Motong Liu
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin Province, People’s Republic of China
Yanyan Wu
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin Province, People’s Republic of China
Song Ni
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin Province, People’s Republic of China
Jiayu Gong
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin Province, People’s Republic of China
Yifei Chen
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin Province, People’s Republic of China
Yuan He
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin Province, People’s Republic of China
Shutong Chen
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin Province, People’s Republic of China
Haitao Yu
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin Province, People’s Republic of China
Lin Xie*
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin Province, People’s Republic of China
*
*Corresponding author: Lin Xie, email xielin@jlu.edu.cn
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Abstract

The influence of the SNP rs174575 (C/G) within the fatty acid desaturase 2 gene on the levels of long-chain PUFA was determined through statistical meta-analysis. Six databases were searched to retrieve the relevant literature. Original data were analysed using Stata 17·0, encompassing summary statistics, tests for heterogeneity, assessment of publication bias, subgroup analysis and sensitivity analysis. A total of ten studies were identified and grouped into twelve trials. Our results showed that individuals who carried the minor G allele of rs174575 had significantly higher dihomo-γ-linolenic acid levels (P = 0·005) and lower arachidonic acid levels (P = 0·033) than individuals who were homozygous for the major allele. The subgroup analysis revealed that the G-allele carriers of rs174575 were significantly positively correlated with linoleic acid (P = 0·002) and dihomo-γ-linolenic acid (P < 0·001) and negatively correlated with arachidonic acid (P = 0·004) in the European populations group. This particular SNP showed a potential association with higher concentrations of dihomo-γ-linolenic acid (P = 0·050) and lower concentrations of arachidonic acid (P = 0·030) within the breast milk group. This meta-analysis has been registered in the PROSPERO database (ID: CRD42023470562).

Keywords

LC-PUFAFADS2 geneSNPMeta-analysis
Type
Systematic Review
Information
British Journal of Nutrition , Volume 132 , Issue 11 , 14 December 2024 , pp. 1423 - 1432
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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