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Dietary factors and rheumatoid arthritis: new perspectives from a Mendelian randomisation analysis

Published online by Cambridge University Press:  05 December 2024

Yidian Wang Open the ORCID record for Yidian Wang [Opens in a new window] ,
Shouye Hu ,
Weisong Zhang ,
Binfei Zhang  and
Zhi Yang
Yidian Wang*
Affiliation:
Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China
Shouye Hu
Affiliation:
Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China
Weisong Zhang
Affiliation:
Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China
Binfei Zhang
Affiliation:
Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China
Zhi Yang*
Affiliation:
Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China
*
Corresponding authors: Zhi Yang; Email: xgcgfd@126.com; Yidian Wang; Email: 1130414968@qq.com
Corresponding authors: Zhi Yang; Email: xgcgfd@126.com; Yidian Wang; Email: 1130414968@qq.com
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Abstract

Rheumatoid arthritis (RA) is a prevalent autoimmune disease, and there is growing evidence suggesting a potential correlation between dietary factors and the pathogenesis of this condition. In order to investigate the causal relationship between diet and RA, we conducted a two-sample Mendelian randomisation (MR) analysis to examine the causal associations between twenty-two dietary factors and RA. Summary data from genome-wide association studies (GWAS) of RA were obtained from large GWAS meta-analyses. GWAS summary data for twenty-two dietary factors were obtained from UK Biobank. Random-effects inverse variance weighted was used as the primary method for assessing causality, and analyses of heterogeneity and horizontal pleiotropy were performed to ensure the accuracy of the results. Research indicates a negative genetic causal relationship between cereal intake (OR = 0·64, 95 % CI: 0·41, 0·99, P = 0·048) and oily fish intake (OR = 0·70, 95 % CI: 0·52, 0·95, P = 0·020) with the risk of RA. Other dietary factors were not causally related to RA. Sensitivity analysis shows that our results are reliable. This study provides genetic evidence suggesting that cereal intake and oily fish intake are protective factors for RA, indicating that RA patients and individuals at high risk should make appropriate dietary adjustments.

Keywords

Rheumatoid arthritisMendelian randomisationDietSingle-nucleotide polymorphismGenome-wide association studies
Type
Research Article
Information
British Journal of Nutrition , Volume 133 , Issue 1 , 14 January 2025 , pp. 107 - 117
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors contributed equally to this work.

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