Recent discussion has emphasized the importance of assessments of clinicalsignificance of outcome in treatment outcome studies. Several methods existto assess clinical significance, one of which is the use of global ratingsof outcome. This study reports the use of such measures in a treatmentoutcome study investigating pharmacological and psychologicaltreatments for panic disorder and agoraphobia in primary care. Outcome isreported in terms of global ratings of symptom severity and of change insymptoms following treatment, completed by the psychologist, referringGeneral Practitioners (GPs) and patients. Treatments involving cognitivebehaviour therapy showed greater efficacy than those employingpharmacological treatments alone. Considerable agreement was demonstratedbetween psychologist and patient ratings. Such agreement was much lessobvious for ratings completed by referring GPs. Possible reasons for thisare advanced.