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Negative affects are parts of the addiction syndrome

Published online by Cambridge University Press:  29 July 2008

Michel Le Moal
Michel Le Moal
Affiliation:
Neurocentre Magendie, Institut François Magendie, Université VictorSegalen – Bordeaux 2, 33077 Bordeaux cedex, France. lemoal@bordeaux.inserm.fr
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Abstract

Decision-making is a complex activity for which emotions and affects are essential. Maladaptive choices depend on negative affects. Vulnerabilities to drug or non-drug objects depend on previous psychopathological comorbidities. Premorbid individual characteristics allow us to understand why some individuals – and not others – enter into the addiction cycle. Moreover, plasticity of reward neurocircuitry is, at least in past, responsible for these vulnerabilities leading to compulsive drug use.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 31 , Issue 4 , August 2008 , pp. 451 - 452
Copyright
Copyright © Cambridge University Press 2008

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