Hostname: page-component-7f64f4797f-d7bbv Total loading time: 0 Render date: 2025-11-04T15:47:37.877Z Has data issue: false hasContentIssue false
  • English
  • Français

The role of organic selenium in cadmium toxicity: effects on broiler performance and health status

Published online by Cambridge University Press:  10 August 2012

A. Al-Waeli ,
E. Zoidis ,
A. C. Pappas ,
N. Demiris ,
G. Zervas  and
K. Fegeros
A. Al-Waeli
Affiliation:
Department of Nutritional Physiology and Feeding, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece
E. Zoidis*
Affiliation:
Department of Nutritional Physiology and Feeding, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece
A. C. Pappas
Affiliation:
Department of Nutritional Physiology and Feeding, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece
N. Demiris
Affiliation:
Department of Statistics, Athens University of Economics and Business, 76 Patission Street, 10434 Athens, Greece
G. Zervas
Affiliation:
Department of Nutritional Physiology and Feeding, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece
K. Fegeros
Affiliation:
Department of Nutritional Physiology and Feeding, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece
*
†E-mail: ezoidis@aua.gr
Get access

Abstract

This work was part of a project designed to assess whether organic selenium (Se) can protect against the toxic effects of cadmium (Cd). A total of 300 1-day-old, as hatched, broilers were randomly distributed in four dietary treatments with five replicate pens per treatment. In T1 treatment, broilers were fed a diet with 0.3 mg/kg added Se, as Se-yeast, without added Cd; in T2, broilers were fed a diet with 0.3 mg/kg Se and 10 mg/kg Cd; in T3, broilers were fed a diet with 0.3 mg/kg Se and 100 mg/kg of Cd; and in T4 treatment broilers were fed a diet with 3 mg/kg Se and 100 mg/kg Cd. The Cd was added to diets T2, T3 and T4 as CdCl2. On the 4th and 6th week, two broilers per replicate pen were killed in order to obtain whole blood, liver, kidney and breast samples. Body mass, feed conversion ratio and mortality were assessed and haematological analyses were performed. Se and Cd levels in tissues were analysed by inductively coupled plasma mass spectrometry. Broilers supplemented with 0.3 mg/kg Se can tolerate low levels of Cd added to the diets, as there were no significant negative effects on the examined performance parameters, whereas addition of excess Cd led to an impairment of broilers’ performance. Mortality of broilers did not differ between the four dietary treatments at any interval point or the whole period. The examined haematological parameters such as haematocrit, total blood protein concentration, and leukocytes types ranged within physiological values, revealing no negative health effects after simultaneous Cd and Se addition. The present study indicated that Se can help against the negative effects of Cd, but cannot counteract all of its negative effects.

Keywords

antioxidant systembroilercadmium toxicityperformanceselenium-yeast

Information

Type
Nutrition
Information
animal , Volume 7 , Issue 3 , March 2013 , pp. 386 - 393
Copyright
Copyright © The Animal Consortium 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Andersen, O, Nielsen, JB, Nordberg, GF 2004. Nutritional interactions in intestinal cadmium uptake – possibilities for risk reduction. Biometals 17, 543–547.CrossRefGoogle ScholarPubMed
Bounous, DI, Stedman, NL 2000. Normal avian hematology: chicken and turkey. In Schlam's veterinary hematology (ed. BF Feldman, JG Zinkl, NC Jain and OW Schalm), 5th edition, pp. 1145–1154. Wiley-Blackwell, Oxford, UK.Google Scholar
Cang, L, Wang, YJ, Zhou, DM, Dong, YH 2004. Heavy metals pollution in poultry and livestock feeds and manures under intensive farming in Jiangsu Province. Journal of Environmental Science and Technology 16, 371–374.Google Scholar
European Commission (EC) 1998. Council Directive 98/83/EC on the quality of water intended for human consumption. Official Journal of the European Union L 330, 32–54.Google Scholar
EC 2005. Commission Directive 05/87/EC Amending Annex I to Directive 2002/32/EC of the European Parliament and of the Council on undesirable substances in animal feed as regards lead, fluorine and cadmium. Official Journal of the European Union L 318, 19–24.Google Scholar
European Food Safety Authority (EFSA) 2011. Statement on tolerable weekly intake for cadmium. EFSA Panel on Contaminants in the Food Chain (CONTAM). EFSA Journal 9, 1975–1993.Google Scholar
Feroci, G, Badiello, R, Fini, A 2005. Interactions between different selenium compounds and zinc, cadmium and mercury. Journal of Trace Elements in Medicine and Biology 18, 227–234.Google Scholar
Gad, MA, Abd El-Twab, SM 2009. Selenium toxicosis assessment (in vivo and in vitro) and the protective role of vitamin B12 in male quail (Coturnix coturnix). Environmental Toxicology and Pharmacology 27, 7–16.Google Scholar
Grattan, CE, Dawn, G, Gibbs, S, Francis, DM 2003. Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity. Clinical and Experimental Allergy 33, 337–341.Google Scholar
International Agency for Research on Cancer (IARC) 1993. Cadmium and cadmium compounds. In Beryllium, cadmium, mercury and exposures in the glass manufacturing industry. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans (ed. Sine nomine), vol. 58, pp. 119–239. IARC, Lyon, France.Google Scholar
International Council for Standardization in Haematology (ICSH) 2001. International council for standardization in haematology expert panel on cytometry and international society of laboratory hematology task force on platelet counting. Platelet counting by the RBC/platelet ratio method: a reference method. American Journal of Clinical Pathology 115, 460–464.Google Scholar
Jemai, H, Messaoudi, I, Chaouch, A, Kerkeni, A 2007. Protective effect of zinc supplementation on blood antioxidant defense system in rats exposed to cadmium. Journal of Trace Elements in Medicine and Biology 21, 269–273.CrossRefGoogle ScholarPubMed
Jihen, EH, Messaoudi, I, Fatima, H, Kerkeni, A 2008. Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver and kidney of the rat: histology and Cd accumulation. Food and Chemical Toxicology 46, 3522–3527.Google Scholar
Klaassen, CD, Liu, J, Choudhuri, S 1999. Metallothionein: an intracellular protein to protect against cadmium toxicity. Food and Chemical Toxicology 39, 267–294.Google Scholar
Lacour, M, Zunder, T, Restle, A, Schwarzer, G 2004. No evidence for an impact of selenium supplementation on environment associated health disorders – a systematic review. International Journal of Hygiene and Environmental Health 207, 1–13.Google Scholar
Lafuente, A, González-Carracedo, A, Romero, A, Cano, P, Esquifino, AI 2004. Cadmium exposure differentially modifies the circadian patterns of norepinephrine at the median eminence and plasma LH, FSH and testosterone levels. Toxicology Letters 146, 175–182.Google Scholar
Lazarus, M, Orct, T, Jurasoviae, J, Blanuša, M 2009. The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats. Biometals 22, 973–983.Google Scholar
Lehman, LD, Klaassen, CD 1986. Dosage-dependent disposition of cadmium administered orally to rats. Toxicology and Applied Pharmacology 84, 159–167.Google Scholar
Li, YX, Xiong, X, Lin, CY, Zhang, FS, Li, W, Han, W 2010a. Cadmium in animal production and its potential hazard on Beijing and Fuxin farmlands. Journal of Hazardous Materials 177, 475–480.Google Scholar
Li, J-L, Gao, R, Li, S, Wang, J-T, Tang, Z-X, Xu, S-W 2010b. Testicular toxicity induced by dietary cadmium in cocks and ameliorative effect by selenium. Biometals 23, 695–705.Google Scholar
Liu, RL, Li, ST, Wang, XB, Wang, M 2005. Contents of heavy metal in commercial organic fertilizers and organic wastes. Journal of Agro-Environment Science 24, 392–397.Google Scholar
Lopez-Alonso, M, Miranda, M, Castillo, C, Hernandez, J, Garcia-Vaquero, M, Benedito, JL 2007. Toxic and essential metals in liver, kidney and muscle of pigs at slaughter in Galicia, north-west Spain. Food Additives and Contaminants 24, 943–954.Google Scholar
Lunn, DJ, Thomas, A, Best, N, Spiegelhalter, D 2000. WinBUGS – a Bayesian modelling framework: concepts, structure, and extensibility. Statistics and Computing 10, 325–337.Google Scholar
Mahan, DC 1999. Organic selenium: using nature's model to redefine selenium supplementation for animals. In Biotechnology in the feed industry (ed. TP Lyons and KA Jacques), pp. 523–535. Nottingham University Press, Nottingham, UK.Google Scholar
Mahmoud, KZ, Edens, FW 2003. Influence of selenium sources on age related and mild heat stress-related changes of blood and liver glutathione redox cycle in broiler chickens (Gallus domesticus). Comparative Biochemistry and Physiology 136, 921–934.Google Scholar
Martelli, A, Rousselet, E, Dycke, C, Bouron, A, Moulis, JM 2006. Cadmium toxicity in animal cells by interference with essential metals. Biochimie 88, 1807–1814.Google Scholar
Messaoudi, I, Hammouda, F, El Heni, J, Baati, T, Saïd, K, Kerkeni, A 2010. Reversal of cadmium-induced oxidative stress in rat erythrocytes by selenium, zinc or their combination. Experimental and Toxicologic Pathology 62, 281–288.CrossRefGoogle ScholarPubMed
Nolan, TD, Brown, D 2000. The influence of elevated dietary zinc, selenium, and their combination on the suppressive effect of dietary and intraperitoneal cadmium on egg production in laying hens. Journal of Toxicology and Environmental Health 60, 549–565.Google Scholar
Ognjanović, BI, Marković, SD, Dordević, NZ, Trbojević, IS, Štajn, AŠ, Saičić, ZS 2010. Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: protective role of coenzyme Q10 and Vitamin E. Reproductive Toxicology 29, 191–197.Google Scholar
Ognjanović, BI, Marković, SD, Pavlović, SZ, Žikić, RV, Štajn, AŠ, Saičić, ZS 2008. Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: protective effect of selenium. Physiological Research 57, 403–411.Google Scholar
Pappas, AC, Zoidis, E, Surai, PF, Zervas, G 2008. Selenoproteins and maternal nutrition. Comparative Biochemistry and Physiology 151, 361–372.Google Scholar
Pappas, AC, Zoidis, E, Fegeros, K, Zervas, G, Surai, PF 2010. Cadmium toxicity and the antioxidant system. Environmental health – physical, chemical and biological factors series. Nova Science Publishers, New York, NY, USA.Google Scholar
Pappas, AC, Zoidis, E, Georgiou, CA, Demiris, N, Surai, PF, Fegeros, K 2011. Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken. Food Additives and Contaminants 28, 446–454.Google Scholar
Payne, RL, Lavergne, TK, Southern, LL 2005. Effect of inorganic versus organic selenium on hen production and egg selenium concentration. Poultry Science 84, 232–237.Google Scholar
Petersson-Grawé, K, Thierfelder, T, Jorhem, L, Oskarsson, A 1997. Cadmium levels in kidneys from Swedish pigs in relation to environmental factors – temporal and spatial trends. Science of the Total Environment 208, 111–122.Google Scholar
Rayman, MP 2004. The use of high-selenium yeast to raise selenium status: how does it measure up? British Journal of Nutrition 92, 557–573.Google Scholar
Sasakura, C, Suzuki, KT 1998. Biological interaction between transition metals (Ag, Cd and Hg), selenide/ sulfide and selenoprotein P. Journal of Inorganic Biochemistry 71, 159–162.Google Scholar
Schrauzer, GN 2009. Selenium and selenium-antagonistic elements in nutritional cancer prevention. Critical Reviews in Biotechnology 29, 10–17.Google Scholar
Strachan, S 2010. Trace elements. Current Anaesthesia and Critical Care 21, 44–48.Google Scholar
Valko, M, Morris, H, Cronin, MTD 2005. Metals, toxicity and oxidative stress. Current Medical Chemistry 12, 1161–1208.Google Scholar
Zoidis, E, Pappas, AC, Georgiou, CA, Komaitis, E, Fegeros, K 2010. Selenium affects the expression of GPx4 and catalase in the liver of chicken. Comparative Biochemistry and Physiology 155, 294–300.Google Scholar