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Genetic diversity of Anaplasma species major surface proteins and implications for anaplasmosis serodiagnosis and vaccine development

Published online by Cambridge University Press:  28 February 2007

José de la Fuente ,
Ala Lew ,
Hans Lutz ,
Marina L. Meli ,
Regina Hofmann-Lehmann ,
Varda Shkap ,
Thea Molad ,
Atilio J. Mangold ,
Consuelo Almazán  and
Victoria Naranjo
...Show all authors
José de la Fuente*
Affiliation:
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078-2007, USA Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13005 Ciudad Real, Spain
Ala Lew
Affiliation:
Department of Primary Industries and Fisheries, Locked Mail Bag No. 4, Moorooka, 4105 qld, Australia
Hans Lutz
Affiliation:
Clinical Laboratory, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland
Marina L. Meli
Affiliation:
Clinical Laboratory, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland
Regina Hofmann-Lehmann
Affiliation:
Clinical Laboratory, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland
Varda Shkap
Affiliation:
Division of Parasitology, Kimron Veterinary Institute, P.O. Box 12, Bet Dagan, 50250, Israel
Thea Molad
Affiliation:
Division of Parasitology, Kimron Veterinary Institute, P.O. Box 12, Bet Dagan, 50250, Israel
Atilio J. Mangold
Affiliation:
Instituto Nacional de Tecnología Agropecuaria, Estación Experimental Agropecuaria Rafaela, CC 22, CP2300 Rafaela, Santa Fe, Argentina
Consuelo Almazán
Affiliation:
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078-2007, USA
Victoria Naranjo
Affiliation:
Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13005 Ciudad Real, Spain
Christian Gortázar
Affiliation:
Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13005 Ciudad Real, Spain
Alessandra Torina
Affiliation:
Istituto Zooprofilattico Sperimentale della Sicilia, Via G. Marinuzzi n°3, 90129 Palermo, Italy
Santo Caracappa
Affiliation:
Istituto Zooprofilattico Sperimentale della Sicilia, Via G. Marinuzzi n°3, 90129 Palermo, Italy
Ana L. García-Pérez
Affiliation:
Departamento de Sanidad Animal, Instituto Vasco de Investigación y Desarrollo Agrario (NEIKER), Berreaga 1, 48160 Derio (Bizkaia), Spain
Marta Barral
Affiliation:
Departamento de Sanidad Animal, Instituto Vasco de Investigación y Desarrollo Agrario (NEIKER), Berreaga 1, 48160 Derio (Bizkaia), Spain
Beatriz Oporto
Affiliation:
Departamento de Sanidad Animal, Instituto Vasco de Investigación y Desarrollo Agrario (NEIKER), Berreaga 1, 48160 Derio (Bizkaia), Spain
Luigi Ceci
Affiliation:
Dipartimento di Sanità e Benessere degli Animali, Sezione di Clinica Medica, Facoltà di Medicina Veterinaria, Università degli studi di Bari, Strada per Casamassima km 3, Valenzano (Ba), Italy
Grazia Carelli
Affiliation:
Dipartimento di Sanità e Benessere degli Animali, Sezione di Clinica Medica, Facoltà di Medicina Veterinaria, Università degli studi di Bari, Strada per Casamassima km 3, Valenzano (Ba), Italy
Edmour F. Blouin
Affiliation:
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078-2007, USA
Katherine M. Kocan
Affiliation:
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078-2007, USA
*
*Email: jose_delafuente@yahoo.com and djose@cvm.okstate.edu
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Abstract

The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several pathogens of veterinary and human medical importance. An understanding of the diversity of Anaplasma major surface proteins (MSPs), including those MSPs that modulate infection, development of persistent infections, and transmission of pathogens by ticks, is derived in part, by characterization and phylogenetic analyses of geographic strains. Information concerning the genetic diversity of Anaplasma spp. MSPs will likely influence the development of serodiagnostic assays and vaccine strategies for the control of anaplasmosis.

Keywords

Anaplasmamajor surface proteinsdiagnosisvaccination
Type
Research Article
Information
Animal Health Research Reviews , Volume 6 , Issue 1 , June 2005 , pp. 75 - 89
Copyright
Copyright © CAB International 2005

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