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The Organization of the Oocyte and Embryogenesis in Twinning and Fusion Malformations

Published online by Cambridge University Press:  01 August 2014

Charles E. Boklage
Charles E. Boklage*
Affiliation:
East Carolina University School of Medicine, Greenville, USA
*
Genetics Program, East Carolina University School of Medicine, Greenville, NC 27858, USA

Abstract

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Certain congenital malformations occur in excess among twins and also among first-degree relatives of twins. In the general population, these anomalies are familially associated with each other, and, like twinning, familially associated with unusual brain function asymmetry. They affect structures built by fusion of bilateral embryonic halves and remodeled under major influence of neural crest mesenchyme. This conjunction of associations suggests that twinning, symmetry development, and this group of malformations might share causai elements at least some of which are heritable. The problem here is the absence of zygosity differences in these relationships, because of which they cannot be explained within the biology of twinning as it has been understood. A potential resolution is offered by way of a mechanism common to MZ and DZ twinning, involving a relationship between oocyte organization and the determination of body symmetries.

Keywords

TwinningLeft handednessMalformationsEpidemiology
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 36 , Issue 3 , July 1987 , pp. 421 - 431
Copyright
Copyright © The International Society for Twin Studies 1987

References

REFERENCES

1.Barr, A, Stevenson, AC (1961): Stillbirths and infant mortality in twin. Ann Hum Genet 25:131–140.CrossRefGoogle Scholar
2.Boklage, CE (1981): On the distribution of nonrighthandedness among twins and their families. Acta Genet Med Gemellol 30:167–187.Google ScholarPubMed
3.Boklage, CE (1981): On the timing of monozygotic twinning events. Prog Clin Biol Res /9A: 155–165.Google Scholar
4.Boklage, CE (1987): Developmental differences between singletons and twins in distributions of dental diameter asymmetries. Am J Phys Anthropol (in press).Google Scholar
5.Boklage, CE (1987): Race, zygosity and mortality among twins: Interaction of myth and method. Acta Genet Med Gemellol 36:Google Scholar
6.Boklage, CE, Fraser, FC (1984): Symmetry-related markers of fusion malformation liability. 17th Annual March of Dimes Birth Defects Conference abstracts.Google Scholar
7.Bomsel-Helmreich, O, Papiernik-Berkhauer, E (1976): Delayed ovulation and monozygotic twinning. Acta Genet Med Gemellol 25:73–76.CrossRefGoogle ScholarPubMed
8.Bulmer, MG (1970): The Biology of Twinning in Man. Oxford: Clarendon Press.Google Scholar
9.Burden, HW, Lawrence, IE Jr, Smith, CP, Hoffman, J, Leonard, M, Fletcher, DJ, Hodson, CA (1986): The effects of vagotomy on compensatory ovarian hypertrophy and follicular activation after unilateral ovariectomy. Anat Rec 214:61–66.CrossRefGoogle ScholarPubMed
10.Burn, J, Corney, G (1984): Congenital heart defects and twinning. Acta Genet Med Gemellol 33: 61–70.Google ScholarPubMed
11.Butcher, RL, Fugo, NW (1967): Overripeness and the mammalian ova. II: Delayed ovulation and chromosome anomalies. Fertil Steril 18:297–302.CrossRefGoogle ScholarPubMed
12.Butcher, RI, Blue, JD, Fugo, NW (1969): Overripeness and the mammalian ova. III: Fetal development at midgestation and at term. Fertil Steril 20:222–231.Google Scholar
13.Carmelli, D, Hasstedt, S, Andersen, S (1981): Demography and genetics of human twinning in the Utah Mormon genealogy. Prog Clin Biol Res 69A:81–94.Google Scholar
14.Corey, LA, Winter, R, Eaves, LJ, Golden, W, Nance, WE (1980): The MZ half-sib design: An approach for the examination of the etiology of congenital malformations. Prog Clin Biol Res 46:437–454.Google Scholar
15.Corney, G, MacGillivray, G, Campbell, DM, Thompson, B, Little, J (1983): Congenital anomalies in twins in Aberdeen and northeast Scotland. Acta Genet Med Gemellol 32:31–35.Google ScholarPubMed
16.Davidson, EH, Firtels, RA (1984): Molecular Biology of Development. New York: Alan R Liss Inc.Google Scholar
17.Denenberg, VH (1984): Behavioral asymmetry. In Geschwind, N, Galaburda, A (eds): Cerebral Dominance: The Biological Foundations. Cambridge, Ma: Harvard Univ Press, pp 114–133.Google Scholar
18.Derom, C, Bakker, E, Vlietinck, RF, Derom, R, Van den Berghe, H, Thiery, M, Pearson, P (1985): Zygosity determination in newborn twins using DNA variants. J Med Genet 22:279–282.CrossRefGoogle ScholarPubMed
19.Derom, C, Derom, R, Vlietinck, R, Van Den Berghe, H, Thiery, M (1987): Increased monozygotic twinning rate after ovulation induction. Lancet i: 1236–1238.Google Scholar
20.Derom, R, Cameron, AH, Edwards, JH, Thiery, M (1983): Zygosity and genetic anomalies in twins. Eur J Obstet Gynecol Reprod Biol 15:269–72.Google Scholar
21.Donahue, RP (1975): Normal and abnormal chromosomal behavior in the meiotic divisions of mammalian oocytes. In Blandau, RJ (ed): Aging Gametes: Their Biology and Pathology. Basel: S Karger, pp 50–71.Google Scholar
22.Donahue, RP, Karp, LE (1973): Chromosomal anomalies after fertilization of aged, post-ovulatory mouse oocytes. Am J Hum Genet 25:24A.Google Scholar
23.Fraser, FC (1983): Association of neural tube defects and parental nonrighthandedness. Am J Hum Genet 35:89A.Google Scholar
24.Fraser, FC, Rex, A (1984): Non-righthandedness: a manifestation of developmental instability. Am J Hum Genet 36:51S.Google Scholar
25.Fraser, FC, Rex, A (1984): Excess of parental nonrighthandedness in children with right-sided cleft lip: A preliminary report. J. Craniofac Genet Devel Biol, Suppl 1:85–88.Google Scholar
26.Freeman, G (1983): The role of egg organization in the generation of cleavage patterns. In Jeffry, WR, Raff, RA (eds): Time, Space, and Pattern in Embryonic Development. New York: Alan R Liss, pp 171–196.Google Scholar
27.Fugo, NW, Butcher, RL (1966): Overripeness and the mammalian ova. I: Overripeness and early embryonic development. Fertil Steril 17:804–814.CrossRefGoogle ScholarPubMed
28.Gerendai, I (1984): Lateralization of neuroendocrine control. In Geshwind, N, Galaburda, A (eds): Cerebral Dominance: The Biological Foundations. Cambridge, MA: Harvard Univ Press, pp 167–178.Google Scholar
29.Giard, A (1876): L'oeuf et les debuts de l'evolution. Bull Sci du Nord de la France: 252–258.Google Scholar
30.Glick, SD, Shapiro, RM (1984): Functional and neurochemical asymettries. In Geschwind, N, Galaburda, A (eds): Cerebral Dominance: The Biological Foundations. Cambridge, MA: Harvard Univ Press, pp 147–166.Google Scholar
31.Guerrero, R (1974): Association of the type and time of insemination within the menstrual cycle with the human sex ratio at birth. N Engl J Med 291:1056–1059.Google Scholar
32.Harlap, S (1979): Gender of infants conceived on different days of the menstrual cycle. N Engl J Med 193:573–575.Google Scholar
33.Harlap, S, Shahar, S, Baras, M (1985): Overripe ova and twinning. Am J Hum Genet 37:1206–1215.Google Scholar
34.Hay, DA, O'Brien, PJ, Johnston, CJ, Prior, M (1984): The high incidence of reading disability in twin boys and its implications for genetic analyses. Acta Genet Med Gemellol 33:223–236.Google ScholarPubMed
35.Hay, S, Wehrung, DA (1970): Congenital malformations in twins. Am J Hum Genet 22:662–678.Google Scholar
36.James, WH (1976): Twinning and anencephaly. Ann Hum Biol 3:401–409.Google Scholar
37.James, WH (1976): Timing of fertilization and sex ratio of offspring – A review. Ann Hum Biol 3:549–556.CrossRefGoogle ScholarPubMed
38.James, WH (1980): Differences between the events proceding spina bifida and anencephaly. J Med Genet 18:17–21.Google Scholar
39.Johnson, MH, Pratt, HPM (1983): Cytoplasmic localizations and cell interactions in the formation of the mouse blastocyst. In: Jeffery, WR, Raff, RA (eds): Time, Space and Pattern in Embryonic Development. Nw York: Alan R Liss Inc, pp 287–312.Google Scholar
40.Johnson, MH, Pratt, HPM, Handyside, AH (1981): The generation and recognition of positional information in the preimplantation mouse embryo. Ch 4. In Glasser, SR, Bullock, DW (eds): Cell and Molecular Aspects of Implantation. New York: Plenum Press.Google Scholar
41.Kramer, AA, Corey, LA, Nance, WE, Magnus, P, Berg, K (1982): Rates of congenital heart defects and oral clefting in the offspring of Norwegian twins. March of DimesBirth Defects Conference Abstracts, p 99.Google Scholar
42.MacGillivray, I, Nylander, PPS, Corney, G: Human Multiple Reproduction. London: WB Saunders.Google Scholar
43.MacMahon, B, Pugh, TF (1954): Sex ratio of white births in the United States during the Second World War. Am J Hum Genet 6:284–292.Google Scholar
44.Marston, JH, Chang, MC (1964): The fertilizable life of ova and their morphology following delayed insemination in mature and immature mice. J Exp Zool 155:237–252.Google Scholar
45.Myrianthopoulos, NC (1976): Congenital malformations in twins. Acta Genet Med Gemellol 25: 331–335.Google Scholar
46.Nora, JJ, Gilliland, JC, Sommerville, RJ, McNamara, DG (1959): Congenital heart disease in twins. N Engl J Med 277:568–571.Google Scholar
47.Rebagliatti, MR, Weeks, DL, Harvey, RP, Melton, DA (1985): Identification and cloning of localized maternal RNAs from Xenopus eggs. Cell 42:769–777.Google Scholar
48.Stevenson, AC, Johnston, HA, Stewart, MIP, Golding, DR (1966): Congenital Malformations: A Report of a Study of Series of Consecutive Births in 24 Centres. Geneva: World Health Organization.Google Scholar
49.Thompson, RS, Zamboni, L (1975): Anomalous patterns of mammalian oocyte maturation and fertilization. Am J Anat 142:233–264.Google Scholar
50.Tisserand, (1944): Dominance latérale et be-de-lièvre. Arch Fr Pediatrie 2:166–167.Google Scholar
51.Windham, GC, Bjerkedal, T (1984): Malformations in twins and their siblings, Norway, 1967-79. Acta Genet Med Gemellol 33:87–96.Google Scholar
52.Witschi, E (1952): Overripeness of the egg as a cause of twinning and teratogenesis: A review. Cancer Res 12:763–786.Google Scholar