The Year 1949 is the two hundredth anniversary of the leave-taking from their native land for American missionary endeavors, of the Mallorquin Franciscans, Junípero Serra, Francisco Palóu, and Juan Crespí. They were, however, but a threesome among the thirty-three who comprised the entire group or “mission” that sailed from Cádiz in the latter part of 1749. The coming anniversary, therefore, suggests the proper occasion to study from the original sources, the methods, chronology, and personalities involved in that great missionary enterprize that meant so much for the Americas. The greater part of the material of this article is based on the expediente, No. 5546, of Contratación, located in the Archivo de Indias, Sevilla, Spain. It is entitled: “Mission de Sn. Franco, para el Collegio de Sn. Fernando de Mexico. Año de 1749.” The writer found it at Sevilla in the fall of 1946.