The Dynamic Bacterial Genome

doi:10.1017/CBO9780511541544

This book provides an in-depth analysis of the mechanisms and biological consequences of genome rearrangements in bacteria. Genome rearrangements are a result of the actions of discrete genetic elements such as conjugative transposons, plasmids, phage, and non-conjugative transposons. Bacteria also contain systems to mediate genetic rearrangements such as the general recombination pathway and specialized endogenous recombination mechanisms. The biological effects of these rearrangements are far-reaching and impact on bacterial virulence, antibiotic resistance and the ability of bacteria to avoid the attentions of the host immune system (e.g. antigenic variation). These rearrangements also provide the raw material on which natural selection can act. Each chapter examines the mechanisms involved in genome rearrangements and the direct biological consequences of these events. This book is written by leading research workers and is an invaluable resource for graduate students and researchers in this field.

Review of the hardback:'The book is well structured, thorough and thoughtful, and a rich source of information about the amazing dynamics of bacterial genomes.'

Source: Microbiology Today

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Contents

Frontmatter
pp i-vi
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Contents
pp vii-viii
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List of Contributors
pp ix-xii
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PART 1 - Basic Mechanisms of Genome Rearrangement in Bacteria
pp 1-2
- By Peter Mullany, Reader, Molecular Microbiology at University College, London
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1 - Mechanisms of homologous recombination in bacteria
pp 3-32
- By Marie-Agnès Petit, Faculté de médecine Necker-Enfants Malades, France
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2 - Introduction to site-specific recombination
pp 33-82
- By Makkuni Jayaram, Section of Molecular Genetics and Microbiology, University of Texas at Austin, Ian Grainge, Blanch Lane, South Mimms
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3 - Site-specific recombination by the serine recombinases
pp 83-120
- By Sally J. Rowland, University of Glasgow, W. Marshall Stark, University of Glasgow
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4 - Mobile introns and retroelements in bacteria
pp 121-148
- By Steven Zimmerly, Department of Biological Sciences, University of Calgary
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PART 2 - Horizontal Gene Transfer and Genome Plasticity
pp 149-150
- By Peter Mullany, Reader, Molecular Microbiology at University College, London
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5 - The F-plasmid, a paradigm for bacterial conjugation
pp 151-206
- By Michael J. Gubbins, Department of Biological Sciences, University of Alberta, William R. Will, Department of Biological Sciences, University of Alberta, Laura S. Frost, Department of Biological Sciences, University of Alberta
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6 - The conjugative transposons: Integrative gene transfer elements
pp 207-234
- By Adam P. Roberts, Division of Microbial Diseases, Eastman Dental Institute for Oral Health Care Sciences, University College London (UCL), University of London, Peter Mullany, Division of Microbial Diseases, Eastman Dental Institute for Oral Health Care Sciences, University College, London (UCL), University of London
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7 - Competence for genetic transformation
pp 235-274
- By Irena Draskovic, Public Health Research Institute, David Dubnau, Public Health Research Institute
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PART 3 - Biological Consequences of the Mobile Genome
pp 275-276
- By Peter Mullany, Reader, Molecular Microbiology at University College, London
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8 - Phase variation and antigenic variation
pp 277-322
- By Richard Villemur, INRS-Institut, Eric Déziel, INRS-Institut
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9 - Pathogenicity islands
pp 323-350
- By Bianca Hochhut, Institut für molekulare Infektionsbiologie, Universität Würzburg, Jörg Hacker, Institut für molekulare Infektionsbiologie, Universität Würzburg
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10 - Biological consequences for bacteria of homologous recombination
pp 351-384
- By Diarmaid Hughes, Department of Cell and Molecular Biology, Tobias Norström, Department of Cell and Molecular Biology
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11 - Horizontal gene transfer and bacterial genomic legacies
pp 385-414
- By James R. Brown, Bioinformatics Division, Genetics Research
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Index
pp 415-424
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Plate Section
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The Dynamic Bacterial Genome

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Contents

Frontmatter
pp i-vi

Contents
pp vii-viii

List of Contributors
pp ix-xii

PART 1 - Basic Mechanisms of Genome Rearrangement in Bacteria
pp 1-2

1 - Mechanisms of homologous recombination in bacteria
pp 3-32

2 - Introduction to site-specific recombination
pp 33-82

3 - Site-specific recombination by the serine recombinases
pp 83-120

4 - Mobile introns and retroelements in bacteria
pp 121-148

PART 2 - Horizontal Gene Transfer and Genome Plasticity
pp 149-150

5 - The F-plasmid, a paradigm for bacterial conjugation
pp 151-206

6 - The conjugative transposons: Integrative gene transfer elements
pp 207-234

7 - Competence for genetic transformation
pp 235-274

PART 3 - Biological Consequences of the Mobile Genome
pp 275-276

8 - Phase variation and antigenic variation
pp 277-322

9 - Pathogenicity islands
pp 323-350

10 - Biological consequences for bacteria of homologous recombination
pp 351-384

11 - Horizontal gene transfer and bacterial genomic legacies
pp 385-414

Index
pp 415-424

Plate Section

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The Dynamic Bacterial Genome

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