The Clozapine Handbook: Stahl's Handbooks

Jonathan M. Meyer; Stephen M. Stahl

doi:10.1017/9781108553575

Real-world and clinical trial data support that clozapine is the only effective antipsychotic for treatment resistant schizophrenia and other severe mental illnesses. Clozapine also reduces rates of suicidality, psychiatric hospitalization and all-cause mortality. However, clozapine is underutilized for two reasons: misunderstandings of its efficacy benefits and misapprehension of, limited knowledge or misinformation about the management of treatment related risks and adverse effects. In response to worldwide efforts to promote clozapine use, this user-friendly Handbook provides clinicians with evidence-based approaches for patient management, as well as logical approaches to the management of clinical situations and adverse effects. It outlines clearly the rationale for specific management decisions and prioritises the options based on this logic. This Handbook is designed for use by clinicians worldwide and is essential reading for all mental health care professionals.

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Contents

The Clozapine Handbook
pp i-ii
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The Clozapine Handbook - Title page
pp iii-iii
Stahl’s Handbooks
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Copyright page
pp iv-iv
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Additional material
pp v-vi
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Contents
pp vii-viii
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Foreword
pp ix-xii
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Introduction
pp 1-9
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1 - The Efficacy Story: Treatment-Resistant Schizophrenia, Psychogenic Polydipsia, Treatment-Intolerant Schizophrenia, Suicidality, Violence, Mania and Parkinson’s Disease Psychosis
pp 10-43
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2 - Addressing Clozapine Positive Symptom Nonresponse in Schizophrenia Spectrum Patients
pp 44-59
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3 - Initiating Clozapine
pp 60-77
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4 - Discontinuing Clozapine and Management of Cholinergic Rebound
pp 78-89
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5 - Binding Profile, Metabolism, Kinetics, Drug Interactions and Use of Plasma Levels
pp 90-113
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6 - Understanding Hematologic Monitoring and Benign Ethnic Neutropenia
pp 114-139
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7 - Managing Constipation
pp 140-157
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8 - Managing Sedation, Orthostasis and Tachycardia
pp 158-171
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9 - Managing Sialorrhea
pp 172-189
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10 - Managing Seizure Risk and Stuttering
pp 190-203
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11 - Managing Metabolic Adverse Effects
pp 204-223
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12 - Fever, Myocarditis, Interstitial Nephritis, DRESS, Serositis and Cardiomyopathy
pp 224-241
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13 - Managing Enuresis and Incontinence, Priapism, Venous Thromboembolism, Neuroleptic Malignant Syndrome, Tardive Dyskinesia and Obsessive Compulsive Disorder
pp 242-257
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14 - Eosinophilia, Leukocytosis, Thrombocytopenia, Thrombocytosis, Anemia, Hepatic Function Abnormalities
pp 258-275
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15 - Special Topics: Child and Adolescent Patients, Elderly Patients, Patients With Intellectual Disability, Pregnancy and Risk for Major Congenital Malformation, Lactation, Overdose, Postmortem Redistribution
pp 276-306
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Index
pp 307-318
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The Clozapine Handbook

Stahl's Handbooks

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Contents

The Clozapine Handbook
pp i-ii

The Clozapine Handbook - Title page
pp iii-iii

Copyright page
pp iv-iv

Additional material
pp v-vi

Contents
pp vii-viii

Foreword
pp ix-xii

Introduction
pp 1-9

1 - The Efficacy Story: Treatment-Resistant Schizophrenia, Psychogenic Polydipsia, Treatment-Intolerant Schizophrenia, Suicidality, Violence, Mania and Parkinson’s Disease Psychosis
pp 10-43

2 - Addressing Clozapine Positive Symptom Nonresponse in Schizophrenia Spectrum Patients
pp 44-59

3 - Initiating Clozapine
pp 60-77

4 - Discontinuing Clozapine and Management of Cholinergic Rebound
pp 78-89

5 - Binding Profile, Metabolism, Kinetics, Drug Interactions and Use of Plasma Levels
pp 90-113

6 - Understanding Hematologic Monitoring and Benign Ethnic Neutropenia
pp 114-139

7 - Managing Constipation
pp 140-157

8 - Managing Sedation, Orthostasis and Tachycardia
pp 158-171

9 - Managing Sialorrhea
pp 172-189

10 - Managing Seizure Risk and Stuttering
pp 190-203

11 - Managing Metabolic Adverse Effects
pp 204-223

12 - Fever, Myocarditis, Interstitial Nephritis, DRESS, Serositis and Cardiomyopathy
pp 224-241

13 - Managing Enuresis and Incontinence, Priapism, Venous Thromboembolism, Neuroleptic Malignant Syndrome, Tardive Dyskinesia and Obsessive Compulsive Disorder
pp 242-257

14 - Eosinophilia, Leukocytosis, Thrombocytopenia, Thrombocytosis, Anemia, Hepatic Function Abnormalities
pp 258-275

15 - Special Topics: Child and Adolescent Patients, Elderly Patients, Patients With Intellectual Disability, Pregnancy and Risk for Major Congenital Malformation, Lactation, Overdose, Postmortem Redistribution
pp 276-306

Index
pp 307-318

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Stahl's Handbooks

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