Rheumatic Diseases: Immunological Mechanisms and Prospects for New Therapies

doi:10.1017/CBO9780511545788

This authoritative review volume provides a wide-ranging account of the immunological mechanisms that underlie many rheumatic diseases. Advances in our understanding of the immunopathology of diseases such as rheumatoid arthritis, ankylosing spondylitis and SLE, are paving the way for the development of effective and rational new therapies. This exciting prospect is an important stimulus for ground-breaking research into these diseases and the investigation of new therapeutic options. As the first book to focus exclusively on this burgeoning area of clinical research, this is an invaluable and contemporary account for all rheumatologists, clinical immunologists and those seeking to develop effective new therapies to combat rheumatic diseases.

‘This is an outstanding contribution.’

Wayne M. Yokoyama - MD, Washington University Medical Center

‘… a stimulating mixture of a dozen relatively short reviews which explore many of the problems faced by investigators in the area … a good read.’

N. A. Staines Source: Rheumatology

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Contents

Frontmatter
pp i-iv
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Contents
pp v-v
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List of contributors
pp vi-viii
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1 - Implications of advances in immunology for understanding the pathogenesis and treatment of rheumatic disease
pp 1-12
- By J. S. H. Gaston
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2 - The role of T cells in autoimmune disease
pp 13-32
- By R. J. Moots, K. W. Wucherpfennig
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3 - The role of MHC antigens in autoimmunity
pp 33-60
- By J. Hoyt Buckner, G. T. Nepom
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4 - B cells: formation and structure of autoantibodies
pp 61-78
- By A. Rahman, F. K. Stevenson, D. A. Isenberg
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5 - The role of CD40 in immune responses
pp 79-92
- By P. Lane
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6 - Manipulation of the T cell immune system via CD28 and CTLA-4
pp 93-118
- By D. M. Sansom, L. S. K. Walker
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7 - Lymphocyte antigen receptor signal transduction
pp 119-152
- By D. R. Alexander
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8 - The role of adhesion mechanisms in inflammation
pp 153-182
- By C. Pitzalis
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9 - The regulation of apoptosis in the rheumatic disorders
pp 183-202
- By J. McNally, A. K. Vaishnaw, K. B. Elkon
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10 - The role of monokines in arthritis
pp 203-224
- By W. B. Van den Berg, F. A. J. Van de Loo
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11 - T lymphocyte subsets in relation to autoimmune disease
pp 225-244
- By F. Ramirez, B. Seddon, D. Mason
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12 - Complement receptors
pp 245-276
- By J. M. Ahearn, A. M. Rosengard
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Index
pp 277-288
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Rheumatic Diseases

Immunological Mechanisms and Prospects for New Therapies

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Contents

Frontmatter
pp i-iv

Contents
pp v-v

List of contributors
pp vi-viii

1 - Implications of advances in immunology for understanding the pathogenesis and treatment of rheumatic disease
pp 1-12

2 - The role of T cells in autoimmune disease
pp 13-32

3 - The role of MHC antigens in autoimmunity
pp 33-60

4 - B cells: formation and structure of autoantibodies
pp 61-78

5 - The role of CD40 in immune responses
pp 79-92

6 - Manipulation of the T cell immune system via CD28 and CTLA-4
pp 93-118

7 - Lymphocyte antigen receptor signal transduction
pp 119-152

8 - The role of adhesion mechanisms in inflammation
pp 153-182

9 - The regulation of apoptosis in the rheumatic disorders
pp 183-202

10 - The role of monokines in arthritis
pp 203-224

11 - T lymphocyte subsets in relation to autoimmune disease
pp 225-244

12 - Complement receptors
pp 245-276

Index
pp 277-288

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Rheumatic Diseases

Immunological Mechanisms and Prospects for New Therapies

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