Recombinant Antibodies for Immunotherapy

doi:10.1017/CBO9780511596773

Recombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, 'arming' mAbs, novel alternative Ab constructs, increasing half-lives, alternative concepts employing non-immunoglobulin scaffolds, novel therapeutic approaches, a market analysis of therapeutic mAbs, and future developments in the field. The concepts and technologies are illustrated by examples of recombinant antibodies being used in the clinic or in development. This book will appeal to both newcomers and experienced scientists in the field, biology and biotechnology students, research and development departments in the pharmaceutical industry, medical researchers, clinicians, and biotechnology investors.

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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Contributors
pp vii-x
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Foreword by Sir Gregory Winter
pp xi-xii
- By Sir Gregory Winter, FRS, Deputy Director: Laboratory of Molecular Biology and MRC Centre for Protein Engineering Cambridge, UK
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Preface
pp xiii-xiv
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RECOMBINANT ANTIBODIES FOR IMMUNOTHERAPY
pp xv-xvi
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PART I - HUMANIZED ANTIBODIES
pp 1-2
- By José W. Saldanha
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1 - Humanization of Recombinant Antibodies
pp 3-19
- By José W. Saldanha
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2 - Immunogenicity Assessment of Antibody Therapeutics
pp 20-42
- By Philippe Stas, Jurgen Pletinckx, Yannick Gansemans, Ignace Lasters
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3 - In Vitro Screening for Antibody Immunogenicity
pp 43-52
- By Frank J. Carr, Matthew P. Baker
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PART II - GENERATION AND SCREENING OF ANTIBODY LIBRARIES
pp 53-54
- By Gerald Beste, David Lowe
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4 - Antibody Libraries from Naïve V Gene Sources
pp 55-65
- By Gerald Beste, David Lowe
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5 - Antibodies from IgM Libraries
pp 66-74
- By Stefan Knackmuss, Vera Molkenthin
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6 - Generation and Screening of the Synthetic Human Combinatorial Antibody Library HuCAL GOLD
pp 75-86
- By Ingo M. Klagge
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PART III - TRANSGENIC HUMAN ANTIBODY REPERTOIRES
pp 87-88
- By Aya Jakobovits
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7 - Therapeutic Antibodies from XenoMouse Transgenic Mice
pp 89-99
- By Aya Jakobovits
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8 - VelocImmune: Immunoglobulin Variable Region Humanized Mice
pp 100-108
- By Andrew Murphy
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PART IV - ANTIBODY EFFECTOR FUNCTION
pp 109-110
- By Ross Stewart, Carl Webster
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9 - Mechanisms of Tumor Cell Killing by Therapeutic Antibodies
pp 111-123
- By Ross Stewart, Carl Webster
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10 - Optimization of Fc Domains to Enhance Antibody Therapeutics
pp 124-143
- By Greg A. Lazar, Aaron K. Chamberlain
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11 - Glycoengineered Therapeutic Antibodies
pp 144-154
- By Peter Brünker, Peter Sondermann, Pablo Umaña
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PART V - ARMING ANTIBODIES
pp 155-156
- By David J. King
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12 - Monoclonal Antibodies for the Delivery of Cytotoxic Drugs
pp 157-173
- By David J. King
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13 - Immunotherapy with Radio-immune Conjugates
pp 174-189
- By Christina A. Kousparou, Agamemnon A. Epenetos
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14 - Immunotherapeutic Antibody Fusion Proteins
pp 190-200
- By Nigel S. Courtenay-Luck, David Jones
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PART VI - NOVEL ANTIBODY FORMATS
pp 201-202
- By Fabrice Le Gall, Melvyn Little
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15 - Alternative Antibody Formats
pp 203-215
- By Fabrice Le Gall, Melvyn Little
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16 - Single-Domain Antibodies
pp 216-230
- By Serge Muyldermans, Gholamreza Hassanzadeh Ghassabeh, Dirk Saerens
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17 - Engineering of Non-CDR Loops in Immunoglobulin Domains
pp 231-240
- By Florian Rüker, Gordana Wozniak-Knopp
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PART VII - ANTIGEN-BINDING REPERTOIRES OF NON-IMMUNOGLOBULIN PROTEINS
pp 241-242
- By Andreas Plückthun
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