Pediatric Thrombotic Disorders

doi:10.1017/CBO9781139028882

This comprehensive and authoritative text summarizes current evidence and provides experienced perspectives on the etiology, diagnosis, and management of pediatric thrombotic disorders, including arterial ischemic stroke and cerebral sinovenous thrombosis. Authored by leaders in the field, individual chapters are devoted to specific anatomic sites and types of thrombosis. State-of-the-art, pediatric-focused chapters aid in diagnostic evaluation and therapeutic decision making, in settings ranging from the most routine to the most complex and challenging patient scenarios. Topics include: extremity and caval deep venous thrombosis; pulmonary embolism; cancer-associated thromboembolism; infection-associated thromboembolism; arterial ischemic stroke; cerebral sinovenous thrombosis; gastrointestinal and visceral thrombosis; developmental hemostasis; thrombophilias; heparin-induced thrombocytopenia/thrombosis syndrome; venous thromboembolism prevention; thrombolysis; and novel anticoagulants, among others. This text is a 'must-have' for practitioners in pediatric hematology, oncology, hematopoietic stem cell transplantation, neurology, hospital medicine, and intensive care.

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Contents

Frontmatter
pp i-iv
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Contents
pp v-v
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List of contributors
pp vi-viii
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Preface
pp ix-ix
- By Neil A. Goldenberg, Johns Hopkins University School of Medicine, Marilyn J. Manco-Johnson, University of Colorado
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Acknowledgments
pp x-x
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Section 1 - Epidemiology, etiology, diagnosis, treatment, outcomes
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Chapter 1 - Extremity and caval deep venous thrombosis
pp 1-15
- By Madhvi Rajpurkar, Wayne State University, Shoshana Revel-Vilk, Hadassah Medical Center
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Chapter 2 - Pulmonary embolism
pp 16-32
- By Suzan Williams, The Hospital for Sick Children, University of Toronto, Michael Wang, University of Colorado
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Chapter 3 - Cerebral sinovenous thrombosis in children and neonates
pp 33-46
- By Mahendranath Moharir, University of Toronto, Gili Kenet, Sheba Medical Center
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Chapter 4 - Gastrointestinal and visceral thromboembolism
pp 47-59
- By Courtney A. Lyle, Billings Clinic, Billings, MT, USA, Christoph Male, Medical University of Vienna, Vienna, Austria
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Chapter 5 - Renal and adrenal vein thromboses
pp 60-71
- By Robert Francis Sidonio, Emory University, Leonardo R. Brandao, The Hospital for Sick Children, Toronto
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Chapter 6 - Cancer and thrombosis
pp 72-87
- By Uma Athale, McMaster University
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Chapter 7 - Epidemiology, etiology, and pathophysiology of infection-associated venous thromboembolism in children
pp 88-106
- By Anjali A. Sharathkumar, Ann & Robert H. Lurie Children’s Hospital, Neil A. Goldenberg, Johns Hopkins University School of Medicine, Anthony K. C. Chan, McMaster University Health Sciences Center
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Section 2 - Special considerations in pediatric patients
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Chapter 8 - Developmental hemostasis I
pp 107-118
- By Paul Monagle, University of Melbourne
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Chapter 9 - Developmental hemostasis II
pp 119-132
- By Marilyn J. Manco-Johnson, University of Colorado
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Chapter 10 - Pediatric thrombophilia evaluation: Considerations for primary and secondary venous thromboembolism prevention
pp 133-141
- By Ulrike Nowak-Göttl, University Hospital of Kiel & Lübeck, Gili Kenet, Sheba Medical Center, Neil A. Goldenberg, Johns Hopkins University School of Medicine
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Chapter 11 - Role of global assays in thrombosis and thrombophilia
pp 142-157
- By Meera Chitlur, Wayne State University, Mindy L. Simpson, Rush University Medical Center, Chicago
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Chapter 12 - Heparin-induced thrombocytopenia and thrombosis syndrome in children
pp 158-165
- By Courtney D. Thornburg, University of California San Diego and Rady Children’s Hospital
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Chapter 13 - Severe thrombophilias
pp 166-179
- By Cameron C. Trenor III, Harvard Medical School, Marilyn J. Manco-Johnson, University of Colorado
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Chapter 14 - Thrombolysis
pp 180-199
- By Donald L. Yee, Baylor College of Medicine, Catherine M. Amlie-Lefond, University of Washington, Peter H. Lin, Baylor College of Medicine
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Chapter 15 - New anticoagulants in children: A review of recent studies and a look to the future
pp 200-206
- By G. Young, University of Southern California, Neil A. Goldenberg, Johns Hopkins University School of Medicine
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Chapter 16 - Prevention of VTE in Children
pp 207-218
- By Brian R. Branchford, University of Colorado, Leslie Raffini, University of Pennsylvania Perlman School of Medicine
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Chapter 17 - Arterial ischemic stroke in children
pp 219-230
- By Timothy J. Bernard, University of Colorado School of Medicine, Ulrike Nowak-Göttl, University Hospital of Kiel & Lübeck
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Index
pp 231-235
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Plate section
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Pediatric Thrombotic Disorders

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Contents

Frontmatter
pp i-iv

Contents
pp v-v

List of contributors
pp vi-viii

Preface
pp ix-ix

Acknowledgments
pp x-x

Section 1 - Epidemiology, etiology, diagnosis, treatment, outcomes

Chapter 1 - Extremity and caval deep venous thrombosis
pp 1-15

Chapter 2 - Pulmonary embolism
pp 16-32

Chapter 3 - Cerebral sinovenous thrombosis in children and neonates
pp 33-46

Chapter 4 - Gastrointestinal and visceral thromboembolism
pp 47-59

Chapter 5 - Renal and adrenal vein thromboses
pp 60-71

Chapter 6 - Cancer and thrombosis
pp 72-87

Chapter 7 - Epidemiology, etiology, and pathophysiology of infection-associated venous thromboembolism in children
pp 88-106

Section 2 - Special considerations in pediatric patients

Chapter 8 - Developmental hemostasis I
pp 107-118

Chapter 9 - Developmental hemostasis II
pp 119-132

Chapter 10 - Pediatric thrombophilia evaluation: Considerations for primary and secondary venous thromboembolism prevention
pp 133-141

Chapter 11 - Role of global assays in thrombosis and thrombophilia
pp 142-157

Chapter 12 - Heparin-induced thrombocytopenia and thrombosis syndrome in children
pp 158-165

Chapter 13 - Severe thrombophilias
pp 166-179

Chapter 14 - Thrombolysis
pp 180-199

Chapter 15 - New anticoagulants in children: A review of recent studies and a look to the future
pp 200-206

Chapter 16 - Prevention of VTE in Children
pp 207-218

Chapter 17 - Arterial ischemic stroke in children
pp 219-230

Index
pp 231-235

Plate section

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Pediatric Thrombotic Disorders

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