Neuronal Growth Cones

Phillip R. Gordon-Weeks

doi:10.1017/CBO9780511529719

'I had the good fortune to behold for the first time that fantastic ending of the growing axon. In my sections of the spinal cord of the three day chick embryo, this ending appeared as a concentration of protoplasm of conical form, endowed with amoeboid movements. It could be compared with a living battering ram, soft and flexible, which advances, pushing aside mechanically the obstacles which it finds in its path, until it reaches the region of its peripheral termination. This curious terminal club, I christened the growth cone.' (Santiago Ramón y Cajal, Recollections of My Life, 1937). In Neuronal Growth Cones, Phillip Gordon-Weeks presents the molecular biology of the behavior of growth cones. The book covers the basic morphology and behavior of growth cones, motility and neurite extension via the growth cone cytoskeleton, pathfinding, intracellular signalling, and synaptogenesis. It is the first detailed, critical analysis of all aspects of growth cone biology.

‘… a rich source of information … Each chapter, and sections within chapters, can be read in isolation making it a useful reference text.’

Tom Pratt and David Price Source: BSDB Newsletter

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Neuronal Growth Cones

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Contents

Frontmatter
pp i-vi

Contents
pp vii-x

Preface
pp xi-xi

Abbreviations
pp xii-xii

1 - Introduction
pp 1-29

2 - Motility and Neurite Extension: The Growth Cone Cytoskeleton
pp 30-74

3 - Pathfinding
pp 75-136

4 - Intracellular Signalling in Growth Cones
pp 137-159

5 - Synaptogenesis
pp 160-173

References
pp 174-254

Index
pp 255-260

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