Published online by Cambridge University Press: 19 May 2022
As the first vital sign, temperature occupies a prominent place in the initial assessment of a patient and is of particular significance in an acutely ill patient in the neurocritical care unit. Its interpretation, measurement, and clinical significance can be confounded by the disruption of the normal thermoregulatory mechanisms of the central nervous system, as well as various pharmacotherapies. This chapter aims to provide the reader with an overview of the clinical approach to fever in the neurocritical care unit. This will encompass a discussion of the common causes of fever, including serotonin syndrome, neuroleptic malignant syndrome, malignant hyperthermia, and paroxysmal sympathetic hyperreactivity. Finally, we describe how temperature can be leveraged as an evidence-based therapeutic tool to help improve neurologic outcomes after cardiac arrest.
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