Biosimulation: Simulation of Living Systems

Daniel A. Beard

doi:10.1017/CBO9781139045582

This practical guide to biosimulation provides the hands-on experience needed to devise, design and analyze simulations of biophysical processes for applications in biological and biomedical sciences. Through real-world case studies and worked examples, students will develop and apply basic operations through to advanced concepts, covering a wide range of biophysical topics including chemical kinetics and thermodynamics, transport phenomena, and cellular electrophysiology. Each chapter is built around case studies in a given application area, with simulations of real biological systems developed to analyze and interpret data. Open-ended project-based exercises are provided at the end of each chapter, and with all data and computer codes available online (www.cambridge.org/biosim) students can quickly and easily run, manipulate, explore and expand on the examples inside. This hands-on guide is ideal for use on senior undergraduate/graduate courses and also as a self-study guide for anyone who needs to develop computational models of biological systems.

"concise, very readable textbook..overall, this is a nicely written text that focuses on the more practical aspect of biosimulation, and avoids bogging down the reader with esoteric mathematical theorems and proofs. Recommended." - M.R. King, CHOICE, December 2012

"...this publication does justice to its central aim of providing practical guidance in the development of mathematical models of biological systems. It would likely serve well as a textbook for a course addressing the main subject areas, and as a reference for researchers working in those areas who wish to build such models or better understand their construction." - Christopher R. Myers, Cornell University, Quarterly Review of Biology, June 2013

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Biosimulation

Simulation of Living Systems

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Contents

Frontmatter
pp i-iv

Contents
pp v-viii

Preface
pp ix-x

Extracts
pp xi-xii

1 - Introduction to simulation of biological systems
pp 1-20

2 - Transport and reaction of solutes in biological systems
pp 21-65

3 - Physiologically based pharmacokinetic modeling
pp 66-104

4 - Cardiovascular systems simulation
pp 105-144

5 - Chemical reaction systems: thermodynamics and chemical equilibrium
pp 145-177

6 - Chemical reaction systems: kinetics
pp 178-204

7 - Chemical reaction systems: large-scale systems simulation
pp 205-229

8 - Cellular electrophysiology
pp 230-261

9 - Appendices: mathematical and computational techniques
pp 262-298

References
pp 299-303

Index
pp 304-307

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Simulation of Living Systems

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