Bacterial Genomics: Genome Organization and Gene Expression Tools

Aswin Sai Narain Seshasayee

doi:10.1017/CBO9781139942225

The study of bacterial genetics has revolutionised with the development of genome sequencing, which let us catalogue the gene content of various clinically and industrially important bacteria and opened up the field of comparative genomics. The research findings on bacterial genetics were further enhanced by the development of allied techniques that allowed interrogation of the interactions and functions of the many components of the genome. These developments accelerated with the widespread adoption of quantitative deep-sequencing approaches. This process allowed both comparative and functional genomics on an unprecedented scale by presenting powerful tools to investigate multiple layers of bacterial adaptation and evolution. This book presents the application of genomic tools to examine bacterial adaptation. The emphasis is on data analysis and interpretation. Much of the material is drawn from the recent, primary literature, which is the most powerful tool in the cutting-edge and fast-growing field of bacterial research.

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Bacterial Genomics

Genome Organization and Gene Expression Tools

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Contents

Frontmatter
pp i-ii

Dedication
pp iii-iv

Contents
pp v-viii

List of Figures
pp ix-xii

Acknowledgements
pp xiii-xiv

1 - Introduction: Bacterial Genomes and Gene Expression
pp 1-3

2 - Comparative Genomics in the Era of Sanger Sequencing
pp 4-35

3 - Studying Bacterial Genome Variation with Microarrays
pp 36-59

4 - Studying Bacterial Genomes using Next-Generation Sequencing
pp 60-88

5 - Genome-Scale Analysis of Gene Expression and its Regulation in Bacteria
pp 89-190

6 - DNA Methylation in Bacteria: A Case for Bacterial Epigenetics
pp 191-206

Index
pp 207-211

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