Bacterial Evasion of Host Immune Responses

doi:10.1017/CBO9780511546266

Our survival as multicellular organisms requires the constant surveillance of our internal and external (mucosal) environments by the multifarious elements of the innate and acquired systems of immunity. The objective of this surveillance, expensive as it is to the organisms, is to recognise and kill invading microorganisms. Over the past fifty years the cells and mediators involved in our immune defences have been painstakingly identified. However, it is only relatively recently that the ability of microorganisms to evade immunity has been recognised and investigated. Bacterial Evasion of Host Immune Responses introduces the reader to the mechanisms used by bacteria to evade both humoral and cellular immune responses, using systems ranging in complexity from the simple quorum sensing molecules - acyl homoserine lactones - to the supramolecular syringe-like devices of type III secretion systems. This book will be of interest to researchers and graduate students in microbiology, immunology, pharmacology and molecular medicine.

- Aa Reduce text
- Aa Enlarge text

View selected items
Save to my bookmarks
Export citations
Download PDF (zip)
Save to Kindle
Save to Dropbox
Save to Google Drive
Save content to
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to .

To save content items to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Please be advised that item(s) you selected are not available.
You are about to save
Your Kindle email address

Please provide your Kindle email.

@free.kindle.com @kindle.com (service fees apply)

By using this service, you agree that you will only keep content for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services

Contents

Frontmatter
pp i-iv
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Contents
pp v-vi
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Contributors
pp vii-xiv
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Preface
pp xv-xvi
- By Brian Henderson, Professor of cell biology and runs the Cellular Microbiology, Research Group, University College, London, Petra C. F. Oyston, Principal Scientist in the microbiology section of the Chemical and Biological Defence Sector, Porton Down, UK
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Part I - Recognition of bacteria
pp 1-2
- By Brian Henderson, Professor of cell biology and runs the Cellular Microbiology, Research Group, University College, London, Petra C. F. Oyston, Principal Scientist in the microbiology section of the Chemical and Biological Defence Sector, Porton Down, UK
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

1 - The dendritic cell in bacterial infection: Sentinel or Trojan horse?
pp 3-20
- By Benjamin M. Chain, Department of Immunology, Windeyer Institute of Medical Sciences, University College, London, 46 Cleveland Street, London W1P 6DB, Janusz Marcinkiewicz, Department of Immunology, Jagiellonian University, Krakow, Poland
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

2 - CD1 and nonpeptide antigen recognition systems in microbial immunity
pp 21-38
- By Kayvan R. Niazi, Division of Dermatology and Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of California, Los Angeles, CA 90095, USA, Steven A. Porcelli, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA, Robert L. Modlin, Division of Dermatology and Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

3 - The NRAMP family: co-evolution of a host/pathogen defence system
pp 39-52
- By Richard Bellamy, Department of Medicine, Singleton Hospital, Sketty, Swansea, SA20FB, United Kingdom
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Part II - Evasion of humoral immunity
pp 53-54
- By Brian Henderson, Professor of cell biology and runs the Cellular Microbiology, Research Group, University College, London, Petra C. F. Oyston, Principal Scientist in the microbiology section of the Chemical and Biological Defence Sector, Porton Down, UK
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

4 - Evasion of complement system pathways by bacteria
pp 55-80
- By Michael A. Kerr, Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital, Medical School, Dundee DD1 9SY, Scotland, Brian Henderson, Cellular Microbiology, Research Group, Eastman Dental Institute, Eastman Dental Institute, University College, London, 256 Gray's Inn Road, London WC1X 8LD, UK
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

5 - Bacterial immunoglobulin-evading mechanisms: Ig-degrading and Ig-binding proteins
pp 81-102
- By Mogens Kilian, Department of Medical Microbiology and Immunology, University of Aarhus, The Bartholin Building, DK-800, Aarhus C, Denmark
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

6 - Evasion of antibody responses: Bacterial phase variation
pp 103-124
- By Nigel J. Saunders, Molecular Infectious Diseases Group, Institute of Molecular, Medicine University of Oxford, Headington, OX3 9DS, UK
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Part III - Evasion of cellular immunity
pp 125-126
- By Brian Henderson, Professor of cell biology and runs the Cellular Microbiology, Research Group, University College, London, Petra C. F. Oyston, Principal Scientist in the microbiology section of the Chemical and Biological Defence Sector, Porton Down, UK
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

7 - Type III secretion and resistance to phagocytosis
pp 127-170
- By Åke Forsberg, Department of Medical Protection, Swedish Defence Research Agency, FOI, S-901 82 Umeå, Sweden, Roland Rosqvist, Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden, Maria Fällman, Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

8 - Bacterial superantigens and immune evasion
pp 171-200
- By John Fraser, School of Biological Sciences, Department of Molecular Medicine, University of Auckland, Private Bag, 92019 Auckland, New Zealand, Vickery Arcus, School of Biological Sciences, University of Auckland, Private Bag, 92019 Auckland, New Zealand, Ted Baker, Thomas Proft, School of Biological Sciences, Department of Molecular Medicine, University of Auckland, Private Bag, 92019 Auckland, New Zealand
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

9 - Bacterial quorum sensing signalling molecules as immune modulators
pp 201-222
- By David Pritchard, Immune Modulation Research Group, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Doreen Hooi, Immune Modulation Research Group, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Eleanor Watson, Sek Chow, Immune Modulation Research Group, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Gary Telford, Immune Modulation Research Group, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Barrie Bycroft, Immune Modulation Research Group, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Siri Ram Chhabra, Department of Medicinal Chemistry, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Christopher Harty, Department of Medicinal Chemistry, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Miguel Camara, Department of Molecular Microbiology, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Stephen Diggle, Department of Molecular Microbiology, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Paul Williams, Department of Molecular Microbiology, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

10 - Microbial modulation of cytokine networks
pp 223-242
- By Brian Henderson, Cellular Microbiology, Research Group, Eastman Dental Institute, University College, London, 256 Gray's Inn Road, London WC1X 8LD, UK, Robert M. Seymour
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

11 - Enterotoxins: Adjuvants and immune inhibitors
pp 243-278
- By Jan-Michael A. Klapproth, Division of Infectious Diseases, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA, Michael S. Donnenberg, Division of Infectious Diseases, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

12 - Type III protein secretion and inhibition of NF-κB
pp 279-294
- By Klaus Ruckdeschel, INSERM U431, Universite Montpelier II, CC100, F34095, Montpelier, Cedex 05, France, Bruno Rouot, INSERM U-432, Montpellier, France, Jürgen Heesemann, Max von Pettenkofer-Institut for Hygiene and Medical Microbiology, Pettenkofestr.9a, 80336 Munich, Germany
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Index
pp 295-304
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Plate section
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Metrics

Total number of HTML views: 0

Total number of PDF views: 0 *

Loading metrics...

Total views: 0 *

Loading metrics...

* Views captured on Cambridge Core between #date#. This data will be updated every 24 hours.

Usage data cannot currently be displayed.

Why this information is here

This section outlines the accessibility features of this content - including support for screen readers, full keyboard navigation and high-contrast display options. This may not be relevant for you.

Accessibility Information

Accessibility compliance for the PDF of this book is currently unknown and may be updated in the future.

Bacterial Evasion of Host Immune Responses

This Book has been cited by the following publications. This list is generated based on data provided by Crossref.

Book description

Refine List

Actions for selected content:

Contents

Frontmatter
pp i-iv

Contents
pp v-vi

Contributors
pp vii-xiv

Preface
pp xv-xvi

Part I - Recognition of bacteria
pp 1-2

1 - The dendritic cell in bacterial infection: Sentinel or Trojan horse?
pp 3-20

2 - CD1 and nonpeptide antigen recognition systems in microbial immunity
pp 21-38

3 - The NRAMP family: co-evolution of a host/pathogen defence system
pp 39-52

Part II - Evasion of humoral immunity
pp 53-54

4 - Evasion of complement system pathways by bacteria
pp 55-80

5 - Bacterial immunoglobulin-evading mechanisms: Ig-degrading and Ig-binding proteins
pp 81-102

6 - Evasion of antibody responses: Bacterial phase variation
pp 103-124

Part III - Evasion of cellular immunity
pp 125-126

7 - Type III secretion and resistance to phagocytosis
pp 127-170

8 - Bacterial superantigens and immune evasion
pp 171-200

9 - Bacterial quorum sensing signalling molecules as immune modulators
pp 201-222

10 - Microbial modulation of cytokine networks
pp 223-242

11 - Enterotoxins: Adjuvants and immune inhibitors
pp 243-278

12 - Type III protein secretion and inhibition of NF-κB
pp 279-294

Index
pp 295-304

Plate section

Metrics

Full text views

Book summary page views

Accessibility standard: Unknown

Why this information is here

Accessibility Information

Bacterial Evasion of Host Immune Responses

Book description

Refine List

Actions for selected content:

Save Search

Contents

Metrics

Full text views

Book summary page views

Accessibility standard: Unknown

Why this information is here

Accessibility Information