Bacterial Cell-to-Cell Communication: Role in Virulence and Pathogenesis

doi:10.1017/CBO9780511541506

Many bacterial diseases are caused by organisms growing together as communities or biofilms. These microorganisms have the capacity to coordinately regulate specific sets of genes by sensing and communicating amongst themselves utilizing a variety of signals. This book examines the mechanisms of quorum sensing and cell-to-cell communication in bacteria and the roles that these processes play in regulating virulence, bacterial interactions with host tissues, and microbial development. Recent studies suggest that microbial cell-to-cell communication plays an important role in the pathogenesis of a variety of disease processes. Furthermore, some bacterial signal molecules may possess immunomodulatory activity. Thus, understanding the mechanisms and outcomes of bacterial cell-to-cell communication has important implications for appreciating host-pathogen interactions and ultimately may provide new targets for antimicrobial therapies that block or interfere with these communication networks.

'This is an interesting book covering intercellular chemical signalling in diverse bacteria … The likely target audience for this book would be senior undergraduates and researchers for whom it would give a good contemporary introduction to signalling in different bacteria.'

George Salmond - University of Cambridge

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Contents

Frontmatter
pp i-vi
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Contents
pp vii-viii
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List of Contributors
pp ix-xii
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Preface
pp xiii-xvi
- By Donald R. Demuth, Professor, University of Louisville School of Dentistry, Richard J. Lamont, Professor, University of Florida
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1 - Quorum sensing and regulation of Pseudomonas aeruginosa infections
pp 1-22
- By Victoria E. Wagner, University of Rochester School of Medicine and Dentistry Rochester, NY USA, Barbara H. Iglewski, University of Rochester School of Medicine and Dentistry Rochester, NY USA
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2 - The Pseudomonas aeruginosa quinolone signal
pp 23-38
- By Everett C. Pesci, The Brody School of Medicine at East Carolina University Greenville, NC USA
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3 - Quorum-sensing-mediated regulation of plant–bacteria interactions and Agrobacterium tumefaciens virulence
pp 39-64
- By Catharine E. White, Department of Microbiology, Cornell University Ithaca, NY USA, Stephen C. Winans, Department of Microbiology, Cornell University Ithaca, NY USA
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4 - Jamming bacterial communications: new strategies to combat bacterial infections and the development of biofilms
pp 65-100
- By Michael Givskov, Center for Biomedical Microbiology BioCentrum Technical, University of Denmark, Morten Hentzer, Carlsberg Biosector Carlsberg A/S, Valby Denmark
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5 - Quorum-sensing-mediated regulation of biofilm growth and virulence of Vibrio cholerae
pp 101-116
- By Jun Zhu, University of Pennsylvania School of Medicine, John J. Mekalanos, Harvard Medical School Boston, MA USA
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6 - LuxS in cellular metabolism and cell-to-cell signaling
pp 117-150
- By Kangmin Duan, Molecular Microbiology Laboratory Northwest, University Xián China, Michael G. Surette, Faculty of Medicine, University of Calgary Canada
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7 - LuxS-dependent regulation of Escherichia coli virulence
pp 151-174
- By Marcie B. Clarke, University of Texas Southwestern Medical Center Dallas, TX USA, Vanessa Sperandio, University of Texas Southwestern Medical Center Dallas, TX USA
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8 - Quorum sensing and cell-to-cell communication in the dental biofilm
pp 175-198
- By Donald R. Demuth, School of Dentistry University of Louisville, KY USA, Richard J. Lamont, Department of Oral Biology University of Florida Gainesville, FL USA
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9 - Quorum-sensing-dependent regulation of staphylococcal virulence and biofilm development
pp 199-232
- By Jeremy M. Yarwood, Department of Microbiology Carver College of Medicine, University of Iowa, IA USA
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10 - Cell-density-dependent regulation of streptococcal competence
pp 233-268
- By M. Dilani Senadheera, Dental Research Institute, University of Toronto, Toronto, Canada, Celine Levesque, Dental Research Institute, University of Toronto, Toronto, Canada, Dennis G. Cvitkovitch, Dental Research Institute, University of Toronto, Toronto, Canada
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11 - Signaling by a cell-surface-associated signal during fruiting-body morphogenesis in Myxococcus xanthus
pp 269-300
- By Lotte Søgaard-Andersen, Max Planck Institute for Terrestrial Microbiology Marburg, Germany
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Index
pp 301-314
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Plate Section
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Bacterial Cell-to-Cell Communication

Role in Virulence and Pathogenesis

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Contents

Frontmatter
pp i-vi

Contents
pp vii-viii

List of Contributors
pp ix-xii

Preface
pp xiii-xvi

1 - Quorum sensing and regulation of Pseudomonas aeruginosa infections
pp 1-22

2 - The Pseudomonas aeruginosa quinolone signal
pp 23-38

3 - Quorum-sensing-mediated regulation of plant–bacteria interactions and Agrobacterium tumefaciens virulence
pp 39-64

4 - Jamming bacterial communications: new strategies to combat bacterial infections and the development of biofilms
pp 65-100

5 - Quorum-sensing-mediated regulation of biofilm growth and virulence of Vibrio cholerae
pp 101-116

6 - LuxS in cellular metabolism and cell-to-cell signaling
pp 117-150

7 - LuxS-dependent regulation of Escherichia coli virulence
pp 151-174

8 - Quorum sensing and cell-to-cell communication in the dental biofilm
pp 175-198

9 - Quorum-sensing-dependent regulation of staphylococcal virulence and biofilm development
pp 199-232

10 - Cell-density-dependent regulation of streptococcal competence
pp 233-268

11 - Signaling by a cell-surface-associated signal during fruiting-body morphogenesis in Myxococcus xanthus
pp 269-300

Index
pp 301-314

Plate Section

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Bacterial Cell-to-Cell Communication

Role in Virulence and Pathogenesis

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