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Published online by Cambridge University Press: 21 November 2024
Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia generally characterized as a disproportionate tachycardia and orthostatic intolerance upon standing. Though the prevalence of POTS is unknown, there is a significant predominance in premenstrual Caucasian females with the highest rate of first presentation between 15 and 25 years of age. The pathophysiology of POTS is unknown; however, it is thought to be a combination of multiple dysfunctional comorbidities such as impaired intravascular volume regulation, cardiac deconditioning, peripheral autonomic neuropathy, and increased sympathetic tone, which in combination can create an exaggerated sympathetic response to standing.
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