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Published online by Cambridge University Press: 21 November 2024
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy CADASIL and its recessively inherited version CARASIL are cerebral small-vessel diseases caused by missense mutation in the NOTCH 3 gene located on chromosome 19. Interestingly, this locus is the same as seen in familial hemiplegic migraine, and migraine is the first symptom these patients experience in ~40% of cases in Caucasians. However, migraine prevalence varies widely based on ethnic background, occurring less commonly in those of Asian heritage.
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