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2 - Basic science

Published online by Cambridge University Press:  05 August 2013

By
Reinhold Munker  and
Kerry Atkinson
Edited by
Reinhold Munker ,
Gerhard C. Hildebrandt ,
Hillard M. Lazarus  and
Kerry Atkinson
Reinhold Munker
Affiliation:
Louisiana State University, Shreveport
Gerhard C. Hildebrandt
Affiliation:
University of Utah
Hillard M. Lazarus
Affiliation:
Ireland Cancer Center, Case Western Reserve University Hospital, Cleveland
Kerry Atkinson
Affiliation:
University of Queensland
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Summary

The human hemopoietic system

Understanding of the human hemopoietic and immune systems has advanced markedly during the past 30 years. The key components of the human hemopoietic system are the hemopoietic growth factors, the hemopoietic stem cell, and the marrow microenvironment. Transcription factors direct hematopoietic differentiation. Each of these components is detailed further in the following sections.

Hemopoietic growth factors

  • Colony-stimulating factors (CSFs)Granulocyte colony-stimulating factor (G-CSF)Granulocyte–macrophage colony-stimulating factor (GM-CSF)Macrophage colony-stimulating factor (M-CSF)Interleukin (IL)-3ErythropoietinThrombopoietinIL-5

  • Stem cell factorsKit ligand (stem cell factor)Flt ligand

  • Synergistic factorsIL-1IL-6IL-7IL-9IL-10IL-11IL-12Leukemia inhibitory factor (LIF)

  • Inhibitors/bidirectional regulatorsTumor necrosis factor-alpha (TNF-α)Transforming growth factor-beta (TGF-β)Macrophage inflammatory protein-1β (MIP-1β)Interferon gamma (IFN-γ)

Type
Chapter
Information
The BMT Data Book
Including Cellular Therapy
 , pp. 7 - 24
Publisher: Cambridge University Press
Print publication year: 2013

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References

Atkinson, K, ed. 2003. Clinical Bone Marrow and Blood Stem Cell Transplantation: A Reference Textbook. Cambridge: Cambridge University Press.Google Scholar
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