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from Section II - IVF Add-ons
Published online by Cambridge University Press: 25 November 2021
Making evidence-based decisions with a common primary outcome measure is a key tenet of ethical and effective clinical practice in ART in a rapidly evolving scientific landscape. However, interpretation of the evidence must be underpinned by sound biological reasoning, and this is especially true when it comes to adjunct antioxidant supplementation in IVF. Furthermore, study design for assessing natural compounds is typically based on protocols established to assess drug-based therapies that often fail to effectively evaluate efficacy of individual nutrients that occur naturally in vivo and often groups study patients together with many differing aetiologies. Finally, the gold standard in terms of IVF outcome measure is live birth rate (LBR), but it is vital that we move beyond this narrow perspective and consider obstetric and child health outcomes. With this in mind I will describe the role for pre-conceptional treatment with CoQ10.
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