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from Section II - IVF Add-ons
Published online by Cambridge University Press: 25 November 2021
Endometrial scratching, also known as endometrial injury or trauma, is an add-on suggested to boost the chance of IVF success. Although early evidence appeared to demonstrate a benefit from endometrial scratching in women undergoing IVF, these studies were fraught with methodological issues and associated with a high risk of bias. Despite the poor quality of evidence, endometrial scratching became one of the most popular IVF add-ons in many settings. The procedure is also associated with harms including pain, risk of infection, and a cost of up to US$500. More recent evidence from a large, robust, trial reports no evidence of any benefit from endometrial scratching. Pre-specified subgroup analysis did not reveal any population of women who may benefit. Against a backdrop of only poor-quality research, this new evidence spells the end for endometrial scratching.
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