The Myoshirt, an active exosuit, provides gravity compensation for the shoulders. This study evaluated the impact of the Myoshirt on range of motion (ROM), endurance, and activities of daily living (ADLs) performance through tests involving nine participants with varying levels of arm impairments and diverse pathologies. Optical motion capture was used to quantify ROM of the shoulder and elbow joints during isolated movements and functional tasks. Endurance was quantified through a timed isometric shoulder flexion task, and a battery of ADL tasks was used to measure the perceived support of the exosuit, along with changes in movement quality. Feedback and usability insights were gathered with surveys. The Myoshirt did not significantly improve ROM during isolated movements (shoulder flexion, shoulder abduction, and elbow flexion/extension), but during the reaching phase of a functional drinking task elbow extension increased significantly by 13.5% (t = 7.52, p = .002). Participants could also keep their arms elevated 78.7% longer (t = 1.942, p = .047). Patients also reported less perceived difficulty with ADLs while using the device, and a therapist reported improved execution quality. Participants who self-reported severe impairment levels tended to derive greater benefits compared to those with milder impairments. These findings highlight the potential of the Myoshirt as an assistive device, particularly for individuals with severe impairments, while emphasizing the need for further refinement.