Colpectomy and vaginectomy are synonymous. Some patients may prefer the term colpectomy because the term “vagina” may be tainted. Parallel to the growing numbers of transmen transitioning, an increasing demand for colpectomy is observed. The reasons to undergo colpectomy vary from disgust for vaginal discharge, pain due to senile colpitis, dysphoria due to the presence of the vagina, and most importantly a clear reduction of complications during surgical urethra lengthening procedures, or combination thereof. Surgery may be performed at the same time as hysterectomy or may be staged and can be done through a fulguration technique or excisional technique. Access to the vaginal lining can be obtained either vaginally or laparoscopically. Colpectomy to date is still a procedure rarely performed and should be carried out by experienced professionals as complications are rare but potentially severe. Also, vaginal remnants due to incomplete removal of the vaginal lining are a particularly challenging complication. These can occur in isolation or may communicate with the urethra as a fistula or diverticulum.