In light of growing geopolitical tensions between China and the West, the chapter focuses on areas of persistently shared interests and common concerns of humankind. Climate change, the protection of biodiversity and pandemics cannot be addressed in isolation but require common efforts and international cooperation in the dissemination of technologies and knowledge, despite ideological differences. The paper stresses the importance of existing WTO law and sets a trade-related agenda for these areas. Finally, it submits that a future principle of Common Concern of Humankind offers guidance in finding common ground for multilateral negotiations on trade, competition and investment in the WTO. It is capable of protecting the interests of a global community increasingly caught in big-power rivalry.