from Section II - Measuring Emotional Processes
Published online by Cambridge University Press: 16 September 2025
Positron emission tomography (PET) is the most sensitive technique for imaging of human physiology and molecular pathways in vivo. Here we provide an overview of PET instrumentation and modelling and illustrate how different PET techniques can be used for mapping the molecular basis of the human emotion circuit. We first cover the principles of PET imaging and the most common imaging targets, modelling methods, and experimental designs in brain PET. We then describe how metabolic studies and neuroreceptor mapping of the endogenous dopamine, opioid, serotonin, and cannabinoid systems have contributed to our understanding of the emotional brain. Finally, we review the recent state-of-the art developments in PET-fMRI and total-body PET, and discuss how these techniques can transform the landscape of systems-level biological imaging of the emotion circuits across the brain and periphery.
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