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Chapter 22 - Preterm Birth

Published online by Cambridge University Press:  16 October 2025

Sir Sabaratnam Arulkumaran
Affiliation:
St George's Hospital Medical School, University of London
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Summary

Preterm birth (PTB) is the leading cause of perinatal mortality and morbidity. The long-term health problems associated with PTB are significant. Despite many strategies to identify and treat preterm birth and labour, there remains slow progress in reducing the rates of PTBs. The causes of PTBs are multifactorial. There needs to be a good and coordinated approach to the identification of risk factors, screening strategies and appropriate interventions to have any impact on reducing the rates of PTBs worldwide. Currently, there is no single diagnostic test that should be used exclusively to direct management in the setting of threatened preterm labour. Tests to stratify risks of PTB include biochemical markers such as fetal fibronectin and transvaginal ultrasound of cervical length. Common interventions for preterm labour include tocolysis, antenatal corticosteroids and magnesium sulphate for neuroprotection. This chapter analyses the causes and risk factors for PTB, screening strategies and preventative initiatives to prevent PTB, and reviews the evidence and current guidelines in the screening and prevention of PTB.

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Publisher: Cambridge University Press
Print publication year: 2025

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