Vernacular discourse about science reveals theorizations of it as a power-laden, morally charged experimentation with the world guided by (often implicit) ethical orientations. Applying these vernacular theorizations to interpret professional class science on the continent, the author argues that this science has been shaped most profoundly by the politics of independence. While indigenous projects, European imperialism, and neoliberalism shape scientific institutions, African independence continues to inform the moral and political ends toward which science is thought to work. Understanding the alignment of professional class science with nation-building can help guide the recalibration of science toward the goal of substantive independence.