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Edited by
Dennis S. Chi, Memorial Sloan-Kettering Cancer Center, New York,Nisha Lakhi, Richmond University Medical Center, Staten Island,Nicoletta Colombo, University of Milan-Bicocca
Uterine leiomyosarcomas are rare diseases but represent the commonest subtype of uterine sarcomas. For patients with early-stage localized disease, it is well-known that surgery is the most important part of treatment. However, approximately 40% of patients will present recurrent disease with distant metastasis, and for these patients the question arises as to whether they should have secondary cytoreductive surgery or systemic therapy alone. Decision making needs to take various factors into consideration, as only carefully selected patients will benefit from surgery. Patients for whom surgery is most likely to be beneficial are those with small-volume metastatic disease and late recurrences. In contrast, patients with rapidly progressive disease, or those for whom surgery will not achieve complete macroscopic removal, are unlikely to benefit from surgery, which should be avoided.
The uterus is divided into four anatomical parts. The fundus is the uppermost part and extends into the interstitial portion of the fallopian tubes laterally. The corpus is the main body of the uterus, and the isthmus is the lowermost portion, which extends into the cervix. The lower uterine segment in the pregnant uterus forms at the isthmus, which is at the level of the reflection of the urinary bladder in the non-pregnant uterus. Uterine fibroids are the most common uterine abnormality encountered in women of reproductive age. Ultrasound has the advantages of being a widely available outpatient imaging modality, with the ability to measure and assess the depth of fibroid involvement into the myometrium more accurately than any other imaging technique. Uterine sarcoma is a rare tumour of the uterine myometrium that is usually diagnosed after hysterectomy. The clinical presentation is enlarging uterus in a post-menopausal woman.
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