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Chapter 8.2 - Cerebral Amyloid Angiopathy
from 8 - Other Non-inflammatory Vasculopathies
- By Matija Zupan
Edited by Derya Uluduz, Istanbul Üniversitesi
Anita Arsovska
Book:

Rare Causes of Stroke

Published online:

06 October 2022

Print publication:

01 September 2022, pp 314-320
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Summary

Cerebral amyloid angiopathy (CAA) is characterised by the deposition of Aß proteins in the media and adventitia of small and mid-sized cortical and leptomeningeal arteries (and, less frequently, veins). It is a component of any disorder in which amyloid is deposited in the brain, and it is not associated with systemic amyloidosis. The prevalence of CAA increases with advancing age. Some autopsy series have found CAA in 5% of individuals in the seventh decade but in 50% of those older than 90 years. While often asymptomatic, CAA is being increasingly recognised as an important cause of ICH in the elderly, accounting for up to one-fifth of all spontaneous ICH in this group. We present an 82 year-old gentleman who was diagnosed with cSAH and fulfilled the criteria for probable CAA