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In the last decade, laparoscopic surgery had become popular in gynaecological surgery. Advantages of the minimally invasive approach are reduced postoperative morbidity, less postoperative pain and, consequently, less analgesic requirement, early resumption of intestinal activity and reduced length of hospital stay. Ectopic pregnancy occurs in approximately 1–2% of pregnancies and the incidence is increasing. The most common site of ectopic pregnancy is the ampullary tubal portion and less frequently other parts of the tube and uterus (cornual and caesarean scar pregnancy), the cervix, the ovary and the abdominal cavity are affected. All variants of extrauterine pregnancy can be treated by a minimally invasive approach in the majority of cases. Moreover, minimally invasive surgery can be considered the standard therapeutic option for adnexal masses which represent one of the most common gynaecological diseases. In this chapter, we describe the main surgical techniques concerning these two pathologies, which are of great interest for daily gynaecological practice.
A 34-year-old gravida 3, para 3 is undergoing an interval bilateral salpingectomy for permanent sterilization. She is currently using combined oral contraceptive pills (containing ethinyl estradiol/norethindrone) for contraception. Because of side effects associated with the pill, she has opted for permanent sterilization. She understands sterilization is a permanent procedure and is certain she has completed her family. Her pre-procedure pregnancy test was negative. All her deliveries were spontaneous vaginal deliveries. She has no history of easy bleeding or bruising. She has no past medical or surgical history. She is not taking any other medications and she has no known drug allergies.
The majority of ectopic pregnancies occur within the Fallopian tube, with most implanted in the ampullary region. A number of risk factors have been identified for ectopic pregnancy. Transvaginal ultrasound (TVU) has now become the diagnostic technique of choice for ectopic pregnancy. Historically, laparotomy with salpingectomy was the standard treatment for ectopic pregnancy. Laparoscopic surgery has been shown to be superior to laparotomy, making it the surgical approach of choice. A number of drugs have been used for the treatment of ectopic pregnancy including potassium chloride, prostaglandins, hyperosmolar glucose, mifepristone and actinomycin D. However, the most commonly used drug in clinical practice for the treatment of ectopic pregnancy is methotrexate. The reported success rates for expectant management range between 48-100%. Subsequent hysterosalpingography has shown patency for the affected tube in up to 93% of cases of ectopic pregnancy managed expectantly.
This chapter discusses the usefulness of ultrasound in diagnosing normal and abnormal fallopian tubes using two-dimensional (2D) and three-dimensional (3D) transvaginal ultrasonography (TVS) and hysterosalpingo-contrast sonography (HyCoSy). HyCoSy involves the introduction of fluid into the uterine cavity and the fallopian tubes. The role of HyCoSy as a first-line procedure for the assessment of tubal patency has been examined in several studies. In most of the studies, the diagnostic capabilities of HyCoSy have been compared with the established reference methods of hysterosalpingography (HSG) or laparoscopy with dye insufflation, or both, and in the majority of the studies Echovist was used as the ultrasonographic contrast medium. A multicenter study in Scandinavia compared laparoscopic salpingectomy with no intervention prior to the first in vitro fertilization (IVF) cycle. The study demonstrated significant improvement in pregnancy and birth rates after salpingectomy in patients with hydrosalpinges that were large enough to be visible on ultrasound.
Reproductive endocrinologists use the concept of fecundability in addition to discussing pregnancy rates. Fecundability is a valuable clinical and scientific concept, as it creates the framework for the quantitative analysis of fertility potential. The factor affecting prognosis is the age of the female partner. An important part of the basic infertility evaluation is assessment of fallopian tube patency. A hysterosalpingogram (HSG) is the frequently utilized modality for tubal assessment. Patients who are prepared to enter into in-vitro fertilization (IVF) treatment are encouraged to undergo salpingectomy because of very low pregnancy rates after neosalpingostomy, high rate of recurrent occlusion, risk of ectopic pregnancy, and decreased success rates after IVF when hydrosalpinx is present. Ovarian reserve testing should be offered routinely to women over 35, as well as to those with unexplained infertility to respond to conventional infertility treatment, and to those contemplating assisted reproductive technologies (ART) therapy.
This chapter reviews the evidence surrounding the effect of reproductive surgery for tubal abnormalities, endometriosis, and uterine fibroids on in vitro fertilization (IVF) cycle outcome. Salpingectomy and proximal tubal occlusion are two surgical options in the treatment of distal tubal disease. Proximal tubal occlusion represents a significantly less invasive approach, which requires less surgical dissection and operating time while still eliminating retrograde flow of hydrosalpingeal fluid into the endometrial cavity. Consideration should be given to resection of submucosal fibroids and intramural lesions that distort directly impinge upon the endometrial cavity prior to IVF. Pregnancy rates achieved with assisted reproductive technology (ART) have increased progressively in recent years, and in endometriosis, patients achieve levels of success that are significantly higher than those obtained with alternative therapies. The prolonged use of a GnRH agonist, in at least a subset of endometriosis patients, appears to improve IVF cycle outcome.
The incidence of ectopic pregnancies is increased in assisted reproductive technology (ART) due to a higher number of embryos transferred and a higher prevalence of tubal disease in patients undergoing in vitro fertilization (IVF). The incidence of heterotopic pregnancies increased with increasing number of embryos transferred. Ectopic pregnancy occurs usually within the fallopian tubes. Abdominal pain is the most common clinical manifestation. Other symptoms and signs include vaginal spotting, amenorrhea, and a pelvic mass. The recent advances in ultrasound technology and the higher expertise of sonographers have improved the early diagnosis of ectopic pregnancies. The beta sub-unit of human chorionic gonadotropin (hCG) has been used to differentiate a developing viable intrauterine pregnancy from an abnormal pregnancy. Vascular endothelial growth factor (VEGF) is elevated in ectopic pregnancies. Methotrexate and mifepristone are used in the treatment of ectopic pregnancy. Laparoscopy, laparotomy and salpingectomy are the surgical options for treating ectopic pregnancies.
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