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5 results

  • 12 - Perioperative Goal-Directed Hemodynamic Therapy

  • from Section 3 - Practical Use
    • By
  • Edited by Alexandre Joosten, University of California, Los Angeles, Maxime Cannesson, University of California, Los Angeles, Robert G. Hahn, Karolinska Institutet, Stockholm
  • Book:
    Hemodynamic Monitoring and Fluid Therapy during Surgery
    Published online:
    11 April 2024
    Print publication:
    02 May 2024, pp 125-135

  • Summary

    Perioperative goal-directed hemodynamic therapy aims at optimizing global hemodynamics during the perioperative period by titrating fluids, vasopressors, and/or inotropes to reach predefined hemodynamic goals. Current evidence indicates that treating patients according to perioperative goal-directed hemodynamic therapy protocols reduces morbidity and mortality, particularly in patients having high-risk surgery. However, its adoption into clinical practice is still weak.

    This strategy has also improved greatly over the past 40 years. Monitoring technology has evolved to enable very invasive devices to be replaced by much less invasive (and even totally non-invasive) equipment. Simultaneously, our whole approach to monitoring has shifted from using a few static, single measures to a functional, dynamic, and multivariable approach. Finally, we are moving from standard, protocolized hemodynamic strategies to a more personalized approach to ensure appropriate management of each patient. For this purpose, closed-loop systems are an appealing added value to ensure that therapies are delivered appropriately to all patients.

  • 26 - Can Perfusion Index Be Useful for Fluid and Hemodynamic Management?

  • from Section 4 - Future Directions
    • By
  • Edited by Alexandre Joosten, University of California, Los Angeles, Maxime Cannesson, University of California, Los Angeles, Robert G. Hahn, Karolinska Institutet, Stockholm
  • Book:
    Hemodynamic Monitoring and Fluid Therapy during Surgery
    Published online:
    11 April 2024
    Print publication:
    02 May 2024, pp 298-309

  • Summary

    Photoplethysmography (PPG) has been extensively used for pulse oximetry monitoring in perioperative and intensive care. However, some components of PPG signal have been employed for other purposes, such as non-invasive hemodynamic monitoring. Perfusion index (PI) is derived from PPG signal and represents the ratio of pulsatile on non-pulsatile light absorbance or reflectance of the PPG signal. PI determinants are complex and closely interlinked, involving and reflecting the interaction between peripheral and central hemodynamic characteristics, such as vascular tone and stroke volume. Several studies have shed light on the interesting performances of this variable, especially for hemodynamic monitoring in perioperative and intensive care.

    In the first section of this chapter the physiological and pathophysiological determinants of PI are exposed, along with relevant measuring techniques and potential limitations. Second, the existing data concerning the usefulness of PI in different clinical settings are presented and discussed. Lastly, we review known perspectives and identify new perceptions concerning the use of PI that should be explored regarding its utilization.

  • Prehospital Blood Product Administration Opportunities in Ground Transport ALS EMS – A Descriptive Study

  • Felicia M. Mix, Martin D. Zielinski, Lucas A. Myers, Kathy S. Berns, Anurahda Luke, James R. Stubbs, Scott P. Zietlow, Donald H. Jenkins, Matthew D. Sztajnkrycer
  • Journal:
    Prehospital and Disaster Medicine / Volume 33 / Issue 3 / June 2018
    Published online by Cambridge University Press:
    19 April 2018, pp. 230-236
    Print publication:
    June 2018
  • Introduction

    Hemorrhage remains the major cause of preventable death after trauma. Recent data suggest that earlier blood product administration may improve outcomes. The purpose of this study was to determine whether opportunities exist for blood product transfusion by ground Emergency Medical Services (EMS).

    Methods

    This was a single EMS agency retrospective study of ground and helicopter responses from January 1, 2011 through December 31, 2015 for adult trauma patients transported from the scene of injury who met predetermined hemodynamic (HD) parameters for potential transfusion (heart rate [HR]≥120 and/or systolic blood pressure [SBP]≤90).

    Results

    A total of 7,900 scene trauma ground transports occurred during the study period. Of 420 patients meeting HD criteria for transfusion, 53 (12.6%) had a significant mechanism of injury (MOI). Outcome data were available for 51 patients; 17 received blood products during their emergency department (ED) resuscitation. The percentage of patients receiving blood products based upon HD criteria ranged from 1.0% (HR) to 5.9% (SBP) to 38.1% (HR+SBP). In all, 74 Helicopter EMS (HEMS) transports met HD criteria for blood transfusion, of which, 28 patients received prehospital blood transfusion. Statistically significant total patient care time differences were noted for both the HR and the SBP cohorts, with HEMS having longer time intervals; no statistically significant difference in mean total patient care time was noted in the HR+SBP cohort.

    Conclusions

    In this study population, HD parameters alone did not predict need for ED blood product administration. Despite longer transport times, only one-third of HEMS patients meeting HD criteria for blood administration received prehospital transfusion. While one-third of ground Advanced Life Support (ALS) transport patients manifesting HD compromise received blood products in the ED, this represented 0.2% of total trauma transports over the study period. Given complex logistical issues involved in prehospital blood product administration, opportunities for ground administration appear limited within the described system.

    MixFM, ZielinskiMD, MyersLA, BernsKS, LukeA, StubbsJR, ZietlowSP, JenkinsDH, SztajnkrycerMD. Prehospital Blood Product Administration Opportunities in Ground Transport ALS EMS – A Descriptive Study. Prehosp Disaster Med. 2018;33(3):230–236.

  • (A1) Acute Adrenal Insufficiency after Single Dose Etomidate

  • Lisgelia Santana
  • Journal:
    Prehospital and Disaster Medicine / Volume 24 / Issue S1 / February 2009
    Published online by Cambridge University Press:
    17 February 2017, p. s1
    Print publication:
    February 2009
    • Article
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  • Hemodynamic response patterns: Responder type differences in reactivity and recovery

  • KEITH A. KLINE, PATRICE G. SAAB, MARIA M. LLABRE, SUSAN B. SPITZER, JOVIER D. EVANS, PAIGE A. GREEN McDONALD, NEIL SCHNEIDERMAN
  • Journal:
    Psychophysiology / Volume 39 / Issue 6 / November 2002
    Published online by Cambridge University Press:
    06 January 2003, pp. 739-746
    Print publication:
    November 2002

  • We examined whether responder type groups reflecting patterns of hemodynamic reactivity might also differ in recovery responses. Cardiac output (CO), total peripheral resistance (TPR), systolic and diastolic blood pressure, heart rate, and Heather index were assessed at rest and during speech and cold pressor tasks in young adults. Participants (n = 152) were classified as myocardial, vascular, or mixed-mild responders based on CO and TPR responses to speech presentation. Vascular responders exhibited slower CO and TPR speech recovery than the myocardial and/or mixed-mild groups. Responder type differences in reactivity showed limited task-generalizability. The sustained vascular response pattern of the vascular group is consistent with that seen in hypertension. In light of associations of heightened TPR with markers of disease risk, this suggests potentially negative health implications for vascular responders.