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A life event is an environmental circumstance that has an identifiable onset and ending and may carry the potential for altering individual's present state of mental or physical well-being. Whilst there is now considerable evidence that undesirable life events do precede and increase the risk for depression in adolescents and adults, how they exert their effects remains unclear. To date, the findings indicate that an onset of major depression may occur as a consequence of a range of recent life events and difficulties from either the familial or peer group domain. The findings on both prospective community and longitudinal clinical studies that have carried out concurrent hormone measurement implicate nonpsychosocial processes in the onset and maintenance of depression. Future research clearly requires a combined approach both in terms of the design of studies and collaboration between behavioural and neuroscientists.
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