This work assesses the potential of Sentinel-2A images in precision agriculture for Barley production in a case study. Two workflows are proposed: 1) images were acquired with a relatively simple methodology to follow the crop development; 2) two images around harvest time were downloaded and processed using a more complex and accurate methodology to calculate four vegetation indices (NDVI, WDRVI, GRVI and GNDVI) to be correlated to yield with linear regression models. Yield data were acquired with a yield monitor installed in a combine harvester. Green-based vegetation indices performed slightly better. However, the highest correlation coefficient was 0.48. Better results may be achieved with earlier imagery and other vegetation indices. Sentinel-2 is a promising tool for precision agriculture in large arable crop fields.