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The authors describe the cases of three patients presenting a major extrapyramidal symptom with rising CPK, inconstant hyperthermia and autonomic dysfunction. Through a brief review of the literature, the authors question the unity of the malignant syndrome. If hypertonia is quite constant, the rise in the seric CPK is aspecific and hyperthermia is inconstant.

Neuroleptic Malignant Syndrome (NMS) is a rare but potentially fatal reaction to neuroleptic medication. Both the incidence and aetiology of the NMS are matters of considerable controversy. We present a clustering of cases of NMS in a distinct geographical area in South Wales. Five cases were reported in an eight month period in 1990 and more recently, a second cluster of three cases occurred in a three week period in November, 1991. We discuss some of the possible explanations for this apparent “epidemic” of cases in South Wales.

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Major symptoms and differential diagnosis of neuroleptic malignant syndrome: three case reports

Do cases of neuroleptic malignant syndrome cluster?

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2 results

Major symptoms and differential diagnosis of neuroleptic malignant syndrome: three case reports

Do cases of neuroleptic malignant syndrome cluster?