Neuropsychological and motor deficits in Parkinson's disease that
may contribute to driving impairment were examined in a cohort study
comparing patients with Parkinson's disease (PD) to patients with
Alzheimer's disease (AD) and to healthy elderly controls. Nondemented
individuals with Parkinson's disease [Hoehn & Yahr (H&Y)
stage I–III], patients with Alzheimer's disease
[Clinical Demetia Rating scale (CDR) range 0–1], and
elderly controls, who were actively driving, completed a
neuropsychological battery and a standardized road test administered by a
professional driving instructor. On-road driving ability was rated on
number of driving errors and a global rating of safe, marginal, or unsafe.
Overall, Alzheimer's patients were more impaired drivers than
Parkinson's patients. Parkinson's patients distinguished
themselves from other drivers by a head-turning deficiency. Drivers with
neuropsychological impairment were more likely to be unsafe drivers in
both disease groups compared to controls. Compared to controls, unsafe
drivers with Alzheimer's disease were impaired across all
neuropsychological measures except finger tapping. Driving performance in
Parkinson's patients was related to disease severity (H&Y),
neuropsychological measures [Rey Osterreith Complex Figure (ROCF),
Trails B, Hopkins Verbal List Learning Test (HVLT)-delay], and
specific motor symptoms (axial rigidity, postural instability), but not to
the Unified Parkinson Disease Rating Scale (UPDRS) motor score.
Multifactorial measures (ROCF, Trails B) were useful in distinguishing
safe from unsafe drivers in both patient groups. (JINS, 2005,
11, 766–775.)