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1 results

  • Rhinitis symptoms and quality of life in patients with chronic perennial rhinitis treated with desloratadine

  • H C K Lam, M C F Tong, C A Van Hasselt
  • Journal:
    The Journal of Laryngology & Otology / Volume 121 / Issue 12 / December 2007
    Published online by Cambridge University Press:
    19 July 2007, pp. 1151-1155
    Print publication:
    December 2007
  • Objective:

    To evaluate the outcome and the change in quality of life of patients with chronic rhinitis after treatment with desloratadine.

    Study design:

    A prospective, open-label, non-blinded, non-randomised study of patients in a secondary and tertiary ENT referral centre.

    Methods:

    Chinese patients with chronic rhinitis were recruited. The patients were assessed by a questionnaire that included rhinitis symptoms score and SF-36 health survey components. Endoscopic assessment was performed with a rigid nasoendoscope and scored according to the modified endoscopic appearance score of Lund and Kennedy. A 12-week course of desloratadine 5 mg daily was prescribed. Patients were re-evaluated after treatment. A total of 47 subjects completed the study.

    Results:

    There were significant reductions in median rhinitis symptoms score, from six to five (p < 0.001), and in median endoscopic appearance score, from five to three (p < 0.001). Patients' general health perception was also improved after treatment (p == 0.022).

    Conclusion:

    Desloratadine may be an effective treatment which provides symptomatic relief and improves the quality of life in patients with chronic rhinitis.